2020-1 / JANUARY 6 (CONTRIBUTORS: SANHONG YU, ELIZABETH GENEGA, MING ZHOU)
A 56 yo man presented with a complaint of hoarseness. Imaging studies revealed multiple nodules in his right lung and an 11 cm mass in his left kidney. Clinically, he was thought to have a kidney cancer with lung metastases. He underwent a radical nephrectomy. PAX8 (image 4) and TTF1 (image 5) immunostains are shown.
Click on the below thumbnails to enlarge photos.
1. What is the correct diagnosis?
a. Clear cell renal cell carcinoma, grade 4
b. Clear cell renal cell with extramedullary hematopoiesis
c. Lung adenocarcinoma metastatic to clear cell renal cell carcinoma
d. Metastatic lung adenocarcinoma