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Case of the Week


2019-21 / JULY 8 (CONTRIBUTOR: JOHN CHEVILLE)

CASE HISTORY



25-year-old white male presents with large renal mass with pulmonary metastases.   A nephrectomy was performed. SDH B immunostain is shown.



Click on the below thumbnails to enlarge photos.

4 photo(s) Updated on: June 27, 2019


Quiz

1.    What testing is appropriate for this patient?

a.       Germline testing for SDH B mutation

b.      Germline testing for fumarate hydratase mutation

c.       Mismatch repair enzyme immunohistochemical stains on tumor tissue

d.      PD-L1 immunohistochemical stain on tumor tissue



2.    What other tumors might this patient have?

a.      Colonic adenocarcinoma

b.      Extra-adrenal paraganglioma

c.       Pancreatic islet cell tumor

d.      B cell lymphoma



3.    What of the following features is not a prognostic features in this tumor?

a.       WHO/ISUP grade

b.      Sarcomatoid features

c.       Coagulative tumor necrosis

d.      Presence of a synchronous paraganglioma








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