2019-21 / JULY 8 (CONTRIBUTOR: JOHN CHEVILLE)
25-year-old white male presents with large renal mass with pulmonary metastases. A nephrectomy was performed. SDH B immunostain is shown.
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1. What testing is appropriate for this patient?
a. Germline testing for SDH B mutation
b. Germline testing for fumarate hydratase mutation
c. Mismatch repair enzyme immunohistochemical stains on tumor tissue
d. PD-L1 immunohistochemical stain on tumor tissue
2. What other tumors might this patient have?
a. Colonic adenocarcinoma
b. Extra-adrenal paraganglioma
c. Pancreatic islet cell tumor
d. B cell lymphoma
3. What of the following features is not a prognostic features in this tumor?
a. WHO/ISUP grade
b. Sarcomatoid features
c. Coagulative tumor necrosis
d. Presence of a synchronous paraganglioma