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Case of the Week


2019-24 / JULY 29 (CONTRIBUTOR: JOHN CHEVILLE)

CASE HISTORY



26-year-old male presents with a “fibrous plaque” of the penis associated with curvature.  The patient undergoes surgery for presumed Peyronie’s disease at which time the surgeon excises the plaque material. The tumor is Keratin-positive. The immunostain shown is INI-1.



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Quiz

 1.   What is the most common site of involvement of penile sarcomas?
a.       Glans
b.       Foreskin
c.       Shaft
d.       Penile urethra


2.     What sarcoma does not occur on the penis?
 a.       Angiosarcoma
 b.       Rhabdomyosarcoma
 c.       Epithelioid sarcoma
 d.       None of the above. 


3.    What is the most useful immunohistochemical panel in this setting?
a.       Keratin, desmin, SOX10, actin
b.       Keratin, desmin, INI-1, S100
c.       Keratin, actin, melan A, HMB45
d.       Keratin, CD45, CD30, S100








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The Genitourinary Pathology Society (GUPS) was formed with the vision of advancing the care of patients with urologic diseases through enhancements of best practices, research, and education in the subspecialty of Urological Pathology.

GUPS is an official Companion Society of the United States and Canadian Academy of Pathology (USCAP).

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