2019-31 / SEPTEMBER 16 (CONTRIBUTOR: SOUNAK GUPTA)
A 53-year-old woman presented with right upper quadrant fullness, increasing abdominal discomfort and a dull ache on her right flank over three months. Subsequently, she underwent excision of a large retroperitoneal peri-pancreatic solid and cystic mass, measuring 17cm in greatest linear dimension. This neoplasm did not appear to involve the adrenal gland. Histopathologic examination revealed a paraganglioma.
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1- Germline mutations in which of the following genes is associated with the development of pheochromocytomas/paragangliomas?
a. MEN1 & RET.
b. MEN1 & VHL.
c. SDHX & TSC1/2.
d. SDHX & FH.