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Case of the Week


2019-6 / MARCH 25 (CONTRIBUTOR: JONATHAN EPSTEIN)

CASE HISTORY



A 54 year old man presented with multiple bone metastases and a mass involving the bladder neck. A TUR of the bladder was performed. On outside stains, the tumor was negative for CD138, kappa and lambda light chains, CD56, CD45, CK7, HMWCK, AE1/3, desmin, and GATA3. Stains performed at our institution were positive for NKX3.1, P501S, PSA and negative for GATA3 and Uroplakin II. E-cadherin was lost in the tumor.

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Quiz

What is the correct diagnosis?

a.    Plasmacytoid urothelial carcinoma

       b.    Poorly differentiated prostatic adenocarcinoma with plasmacytoid features

c.     Plasma cell tumor

d.     Rhabdomyosarcoma




About GUPS

The Genitourinary Pathology Society (GUPS) was formed with the vision of advancing the care of patients with urologic diseases through enhancements of best practices, research, and education in the subspecialty of Urological Pathology.

GUPS is an official Companion Society of the United States and Canadian Academy of Pathology (USCAP).

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