Case of the Week

2019-9 / APRIL 15 (CONTRIBUTOR: JONATHAN EPSTEIN)

CASE HISTORY

A 65 year old man presented with a 3 mm nodule in the bladder.

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5 photo(s) Updated on: April 03, 2019

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Quiz

What is the correct diagnosis?

a. Florid cystitis cystica et glandularis

b. Carcinoid tumor

c. Well differentiated adenocarcinoma of the bladder

d. Prostate adenocarcinoma invading the bladder

Carcinoid tumors of the bladder occur in middle aged adults, range 30-73 years often at the trigone or bladder neck. They are usually small (mean 5 mm., range 2-12 mm) and often appear as a polypoid or smooth-surfaced submucosal nodule. Architecturally, the lesion consists of uniform cuboidal or columnar cells forming pseudoglandular structures, including acini and cribriform glands. Nuclei have finely stippled chromatin with inconspicuous nucleoli. There is a moderate to abundant amount of cytoplasm most often amphophilic but ranging from eosinophilic to basophilic. Mitotic figures are absent. Typically, as in this case, it is accompanied by cystitis glandularis, non-intestinal type. Typically, these small lesions are cured by excision or biopsy. Rarely carcinoid can be large more invasive tumor with a more unpredictable prognosis.

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The Genitourinary Pathology Society (GUPS) was formed with the vision of advancing the care of patients with urologic diseases through enhancements of best practices, research, and education in the subspecialty of Urological Pathology.

GUPS is an official Companion Society of the United States and Canadian Academy of Pathology (USCAP).

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