2020-11 / MARCH 17 (CONTRIBUTOR: CONSTANTINA PETRAKI)
71 y/o male with an incidental 4.8 cm renal tumor treated with partial nephrectomy. The tumour is positive for PAX8, CK7 and KSP-Cadherin. CK20, Vimentin, CD10, AMACR and CA IX are negative. SDHB and Fumarate Hydratase are retained. The Ki-67/MIB1 index is low (≤5%).
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1. What is the correct diagnosis?
b. Eosinophylic variant of chromophobe renal cell carcinoma
c. Hybrid oncocytoma-chromophobe tumor (HOCT)
d. Low-grade oncocytic tumor (LOT)
e. Clear cell renal cell carcinoma with eosinophilic changes