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Case of the Week

2020-19 / May 11 (Contributor: Stephanie J Conrad and Ming Zhou)

A 53 year old male with pT3b prostate cancer developed gross hematuria 20 months after receiving external beam radiation. A cystoscopy showed friable mucosa, which was thought to be suspicious for bladder cancer.

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6 photo(s) Updated on: May 09, 2020
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1. What is the correct diagnosis?

    a. Nested Variant Urothelial Carcinoma (NVUC)

    b. Florid von Brunn Nests

    c. Inverted Papilloma

    d. Inverted Urothelial Carcinoma

    e. Pseudocarcinomatous Epithelial Hyperplasia

2. What immunohistochemical marker with diffuse staining is most useful to support the diagnosis?

   a. CD44

    b. CK 20 

    c. p53

    d. p63

    e. HMW keratin

3. What histological feature supports the diagnosis?

    a. Hyperplastic inverted urothelial nests

    b. Rare mitoses

    c. Irregular urothelial nests associated with infiltrating single cells

    d. Urothelial nests encircling vessels with fibrin deposits

    e. Invasion of the detrusor muscle

About GUPS

The Genitourinary Pathology Society (GUPS) was formed with the vision of advancing the care of patients with urologic diseases through enhancements of best practices, research, and education in the subspecialty of Urological Pathology.

GUPS is an official Companion Society of the United States and Canadian Academy of Pathology (USCAP).



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