2020-20 / May 18 (Contributors: Daniel H. Russell and Salvatore E. Mignano)
A 64 year-old-male presented with hematuria and a mass in the fossa navicularis of the anterior urethra. Past history was notable for Grade Group 5 (Gleason score 4+5=9) pT3b pN0 acinar adenocarcinoma of the prostate. His PSA had an interval increase to 0.569 ng/mL. PSA immunohistochemistry on the tumor showed scattered patchy expression.
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1. What is the diagnosis?
a. Invasive high grade urothelial carcinoma
b. Metastatic prostatic adenocarcinoma (acinar adenocarcinoma; usual-type)
c. Metastatic prostatic adenocarcinoma with neuroendocrine features
d. Metastatic large cell neuroendocrine carcinoma of prostatic origin
e. Primary urothelial large cell neuroendocrine carcinoma