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Case of the Week

2020-20 / May 18 (Contributors: Daniel H. Russell and Salvatore E. Mignano)

A 64 year-old-male presented with hematuria and a mass in the fossa navicularis of the anterior urethra. Past history was notable for Grade Group 5 (Gleason score 4+5=9) pT3b pN0 acinar adenocarcinoma of the prostate. His PSA had an interval increase to 0.569 ng/mL. PSA immunohistochemistry on the tumor showed scattered patchy expression.

Click on the below thumbnails to enlarge photos.

3 photo(s) Updated on: May 14, 2020


1. What is the diagnosis?

   a. Invasive high grade urothelial carcinoma

   b. Metastatic prostatic adenocarcinoma (acinar adenocarcinoma; usual-type)

   c. Metastatic prostatic adenocarcinoma with neuroendocrine features

   d. Metastatic large cell neuroendocrine carcinoma of prostatic origin

   e. Primary urothelial large cell neuroendocrine carcinoma

About GUPS

The Genitourinary Pathology Society (GUPS) was formed with the vision of advancing the care of patients with urologic diseases through enhancements of best practices, research, and education in the subspecialty of Urological Pathology.

GUPS is an official Companion Society of the United States and Canadian Academy of Pathology (USCAP).



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