2020-23 / June 8 (Contributor: Daniel H. Russell)
A 4 month-old boy with an unremarkable past medical history presented with a 9.0 cm renal mass. The patient was radiographically diagnosed and underwent 5 weeks of pre-surgical chemotherapy.
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1. What is the diagnosis?
a. Congenital Mesoblastic Nephroma, cellular variant
b. Wilms Tumor, stromal predominant
c. Clear Cell Sarcoma
d. Malignant Rhabdoid Tumor
e. Intrarenal Yolk Sac Tumor
2. What immunohistochemical stain could be helpful in confirming the diagnosis (via positive expression)?
c. cyclin D1
3. What molecular aberration is characteristic in this tumor?
b. mutations involving WT1
c. internal tandem repeats in BCOR
d. SMARCB1 mutation (INI1 loss)
e. loss of heterozygosity