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Case of the Week


2020-23 / June 8 (Contributor: Daniel H. Russell)


A 4 month-old boy with an unremarkable past medical history presented with a 9.0 cm renal mass. The patient was radiographically diagnosed and underwent 5 weeks of pre-surgical chemotherapy.  



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Updated on: May 28, 2020


Quiz

1. What is the diagnosis?

    a.  Congenital Mesoblastic Nephroma, cellular variant

  b.  Wilms Tumor, stromal predominant

    c.  Clear Cell Sarcoma

    d.  Malignant Rhabdoid Tumor

    e.  Intrarenal Yolk Sac Tumor


2. What immunohistochemical stain could be helpful in confirming the diagnosis (via positive expression)?

a. desmin

b. WT1

c. cyclin D1

d. INI1

e. AFP


3. What molecular aberration is characteristic in this tumor?

a. t(12;15)

b. mutations involving WT1

c. internal tandem repeats in BCOR

d. SMARCB1 mutation (INI1 loss)

e. loss of heterozygosity




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The Genitourinary Pathology Society (GUPS) was formed with the vision of advancing the care of patients with urologic diseases through enhancements of best practices, research, and education in the subspecialty of Urological Pathology.

GUPS is an official Companion Society of the United States and Canadian Academy of Pathology (USCAP).

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