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Case of the Week


2020-26 / June 29 (Contributors: Xiaotun Zhang and Maria Tretiakova)


A 30 year-old male presented with long history of back pain and pain with ejaculation, which led to imaging studies that revealed left renal (3.5cm) and large retroperitoneal mass (6.5cm). He has a history of left undescended testicle as a child. Grossly, the kidney tumor exhibits solid and cystic cut surface on partial nephrectomy. Immunohistochemical stains show positive PAX8, GATA3 and AMACR expression in tumor cells, and negative immunoreactivity for CK7.


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Quiz

1. What is the appropriate next step for definitive diagnosis of this case?


a. Immunohistochemical stain of SALL4, PLAP, OCT3/4 and AFP

b. Immunohistochemical and molecular testing for Fumarate Hydratase deficiency

c. Immunohistochemical stains of TFE3, TFEB and SDHB

d. FISH study for ETV6-NTRK3 gene fusion



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The Genitourinary Pathology Society (GUPS) was formed with the vision of advancing the care of patients with urologic diseases through enhancements of best practices, research, and education in the subspecialty of Urological Pathology.

GUPS is an official Companion Society of the United States and Canadian Academy of Pathology (USCAP).

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