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Case of the Week

2020-33 / August 17 (Contributor: Cheng Wang)

A woman in her early 50s presented with multiple broad-based bladder mucosal lesions seen on cystoscopic examination.

Click on the below thumbnails to enlarge photos.

5 photo(s) Updated on: August 12, 2020
  • Cystoscopic view of the bladder lesions (photo courtesy of Dr. G. Bailey)
  • PAS stain
  • Von Kossa stain


1. What is the correct diagnosis?

a. Metastatic carcinoma

b. Malakoplakia

c. Invasive high-grade urothelial carcinoma

d. Bladder endometriosis

e. Lymphoma

2.  What is the name of the targetoid bodies, which are pathognomonic for this condition?

a. Michaelis-Gutman bodies

b. Aschoff bodies

c.  Asbestos bodies

d. Howell-Jolly bodies

e. Psammoma bodies

3. A Von Kossa stain highlights the targetoid bodies by detecting chemicals containing which of the following minerals?

a. Magnesium

b. Iron

c. Calcium

d. Copper

e. Sodium

About GUPS

The Genitourinary Pathology Society (GUPS) was formed with the vision of advancing the care of patients with urologic diseases through enhancements of best practices, research, and education in the subspecialty of Urological Pathology.

GUPS is an official Companion Society of the United States and Canadian Academy of Pathology (USCAP).



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