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Case of the Week

2020-45 / November 9  

Contributors: Jonathan (Lin) He, Liwei Jia

A man in his 60s presented with right sided abdominal pain. The CT scan of abdomen and pelvis with contrast showed an enhancing plaque-like thickening of the bladder wall. The patient underwent transurethral resection of bladder tumor and subsequent cystectomy, which revealed the lesion shown below.

Click on the below thumbnails to enlarge photos.

3 photo(s) Updated on: November 05, 2020


1. What is the correct diagnosis?

a. Plasmacytoma

b. Urothelial carcinoma, plasmacytoid variant

c. Urothelial carcinoma, sarcomatoid variant

d. Malignant melanoma of the bladder

e. Metastatic invasive lobular carcinoma of male breast

2. Which of the following IHC markers is helpful to differentiate it from other variants of urothelial carcinoma?

a. CD10

b. p63

c. GATA3

d. E-cadherin

e. Her2/neu

3. Which of the following molecular alterations is associated with this entity?

a. Von Hippel-Lindau


c. CDH1


e. None of them

About GUPS

The Genitourinary Pathology Society (GUPS) was formed with the vision of advancing the care of patients with urologic diseases through enhancements of best practices, research, and education in the subspecialty of Urological Pathology.

GUPS is an official Companion Society of the United States and Canadian Academy of Pathology (USCAP).



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