2020-45 / November 9
Contributors: Jonathan (Lin) He, Liwei Jia
A man in his 60s presented with right sided abdominal pain. The CT scan of abdomen and pelvis with contrast showed an enhancing plaque-like thickening of the bladder wall. The patient underwent transurethral resection of bladder tumor and subsequent cystectomy, which revealed the lesion shown below.
Click on the below thumbnails to enlarge photos.
1. What is the correct diagnosis?
b. Urothelial carcinoma, plasmacytoid variant
c. Urothelial carcinoma, sarcomatoid variant
d. Malignant melanoma of the bladder
e. Metastatic invasive lobular carcinoma of male breast
2. Which of the following IHC markers is helpful to differentiate it from other variants of urothelial carcinoma?
3. Which of the following molecular alterations is associated with this entity?
a. Von Hippel-Lindau
e. None of them