2020-5 / FEBRUARY 3 (CONTRIBUTOR: CONSTANTINA PETRAKI)
80 y/o male with hematuria and a bladder tumor. NKX3.1 and prostein immunostains are shown. Otherwise the tumor is positive for AR, PSMA and PSAP and is negative for GATA3, UroplakinII, CKHMW, p63, CK5/6.
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1. What is the correct diagnosis?
a. Giant cell urothelial carcinoma
b. Poorly differentiated urothelial carcinoma with osteoclast-like giant cells
c. Pleomorphic giant cell variant of prostatic adenocarcinoma
d. Sarcomatoid urothelial carcinoma.
e. Urothelial carcinoma with trophoblastic differentiation