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Case of the Week

2020-52 / December 28

Contributors:  Andrea Bakker, Kiril Trpkov

A male in his 80s presented with gross hematuria. On CT of the abdomen, there was a plaque-like thickening of the bladder wall measuring 7 x 6.5 x 2 cm with “fat stranding”. On cystoscopy, no distinct bladder mass was identified and a biopsy was performed.

Click on the below thumbnails to enlarge photos.

3 photo(s) Updated on: December 24, 2020
  • Congo Red
  • Polarized Congo Red


1. What is the correct diagnosis?

a. Scar

b. Vasculitis

c. Post-transurethral resection granuloma

d. Amyloidosis

e. Normal bladder

2.  In primary involvement of the urinary bladder, what is the most common protein involved?

a. Serum amyloid A protein (AA)

b. Transthyretin, wild-type (ATTRwt)

c. Immunoglobulin light chains (AL)

d. β2-microglobulin (AH)

e. Apolipoprotein

About GUPS

The Genitourinary Pathology Society (GUPS) was formed with the vision of advancing the care of patients with urologic diseases through enhancements of best practices, research, and education in the subspecialty of Urological Pathology.

GUPS is an official Companion Society of the United States and Canadian Academy of Pathology (USCAP).



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