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Case of the Week


A 72-year old patient underwent a transurethral resection of the prostate due to clinical diagnosis of nodular hyperplasia. He had a previous transurethral resection of the prostate 18 months earlier. Micrographs show one or two areas of interest in the specimen, the largest area measuring 2.5 mm. The lesion was positive for PAX8 (photo), negative for PSA and Ki67 stained less than 5% of the cells. 

Click on the below thumbnails to enlarge photos.

5 photo(s) Updated on: January 22, 2020


1. What is the correct diagnosis?

    a. Bladder adenocarcinoma involving the prostate

    b. Prostate acinar adenocarcinoma

    c. Nephrogenic adenoma with signet ring morphology 

    d. Clear cell carcinoma of prostatic urethra

    e. Urothelial carcinoma with plasmacytoid morphology 


About GUPS

The Genitourinary Pathology Society (GUPS) was formed with the vision of advancing the care of patients with urologic diseases through enhancements of best practices, research, and education in the subspecialty of Urological Pathology.

GUPS is an official Companion Society of the United States and Canadian Academy of Pathology (USCAP).



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