2020-7 / FEBRUARY 17 (CONTRIBUTOR: DANIEL ATHANAZIO)
A 72-year old patient underwent a transurethral resection of the prostate due to clinical diagnosis of nodular hyperplasia. He had a previous transurethral resection of the prostate 18 months earlier. Micrographs show one or two areas of interest in the specimen, the largest area measuring 2.5 mm. The lesion was positive for PAX8 (photo), negative for PSA and Ki67 stained less than 5% of the cells.
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1. What is the correct diagnosis?
a. Bladder adenocarcinoma involving the prostate
b. Prostate acinar adenocarcinoma
c. Nephrogenic adenoma with signet ring morphology
d. Clear cell carcinoma of prostatic urethra
e. Urothelial carcinoma with plasmacytoid morphology