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Case of the Week

2021-06 / February 08

Contributors:  Aditi Dewan, Sambit K. Mohanty

A man in his mid-60s presented with lower abdominal pain and hematuria. Cystoscopy revealed ulceration of the entire urinary bladder mucosa along with a thickened bladder wall. A transurethral resection of the bladder tumor was performed and submitted for histopathological examination.

Click on the below thumbnails to enlarge photos.

2 photo(s) Updated on: February 04, 2021


1. What is the correct diagnosis?

a.  Plasmacytoma

b.  Rhabdomyosarcoma

c.   Lymphoma

d.   Signet ring cell carcinoma

e.   Plasmacytoid urothelial carcinoma

2.   Mutations in which gene are most commonly encountered in the above entity?

a. TP53


c.  CDH1

d.  EGFR

e.  KRAS

About GUPS

The Genitourinary Pathology Society (GUPS) was formed with the vision of advancing the care of patients with urologic diseases through enhancements of best practices, research, and education in the subspecialty of Urological Pathology.

GUPS is an official Companion Society of the United States and Canadian Academy of Pathology (USCAP).



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