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Case of the Week

2021-12/ March 22

Contributor: Stephanie Conrad, Ming Zhou

A woman in her late 50s with hypertension had an incidentally discovered 1.7 cm right renal mass. She underwent a right partial nephrectomy. Presented are the histological findings. 

Click on the below thumbnails to enlarge photos.

4 photo(s) Updated on: March 15, 2021
  • HE, 40X.
  • HE, 100X
  • HE, 400X.
  • HE, 200X.


1. What is the correct diagnosis?

a) Angiomyolipoma

b) Leiomyoma

c) Renal cell carcinoma with sarcomatous differentiation

d) Gastrointestinal stromal tumor (GIST)

e) Solitary fibrous tumor

2. Which of the following immunohistochemical assays, when positive expression is present, supports the diagnosis?

a) Desmin

b) HMB45

c) Cytokeratins

d) PAX 8

e) STAT6

3. What histological feature supports the diagnosis?

a) Vascular proliferation

b) Rare mitoses

c) Sclerotic background  

d) Dysmorphic blood vessels

e) Spindle cell predominance

About GUPS

The Genitourinary Pathology Society (GUPS) was formed with the vision of advancing the care of patients with urologic diseases through enhancements of best practices, research, and education in the subspecialty of Urological Pathology.

GUPS is an official Companion Society of the United States and Canadian Academy of Pathology (USCAP).



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