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Case of the Week

2021-18/ May 3

Contributors: Anandi Lobo and Sambit K. Mohanty


A man in his late 40s presented with lower abdominal pain and distension. A computed tomographic scan revealed a 7 x 7 cm solid and fairly circumscribed mass in the upper pole of the left kidney.  A radical nephrectomy was performed and the specimen was submitted for pathologic evaluation.


Click on the below thumbnails to enlarge photos.

5 photo(s) Updated on: April 30, 2021


Quiz

1.      What is the correct diagnosis?

a.   Synovial sarcoma

b.  Alveolar rhabdomyosarcoma

c.   CIC-DUX4-associated undifferentiated round cell sarcoma.

d.   Solitary fibrous tumor with round cell morphology

e.   BCOR-CCNB3-associated round cell sarcoma

f.   Ewing’s family of tumor


2.  What is the most common genetic alteration encountered in the above entity?

a.   t(11;22)(EWSR1;FLI1)

b.   t(21;22)(EWSR1;ERG)

c.   CIC-DUX4

d.   NAB2-STAT6

e.   BCOR-CCNB3




About GUPS

The Genitourinary Pathology Society (GUPS) was formed with the vision of advancing the care of patients with urologic diseases through enhancements of best practices, research, and education in the subspecialty of Urological Pathology.

GUPS is an official Companion Society of the United States and Canadian Academy of Pathology (USCAP).

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