2021-18/ May 3
Contributors: Anandi Lobo and Sambit K. Mohanty
A man in his late 40s presented with lower abdominal pain and distension. A computed tomographic scan revealed a 7 x 7 cm solid and fairly circumscribed mass in the upper pole of the left kidney. A radical nephrectomy was performed and the specimen was submitted for pathologic evaluation.
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1. What is the correct diagnosis?
a. Synovial sarcoma
b. Alveolar rhabdomyosarcoma
c. CIC-DUX4-associated undifferentiated round cell sarcoma.
d. Solitary fibrous tumor with round cell morphology
e. BCOR-CCNB3-associated round cell sarcoma
f. Ewing’s family of tumor
2. What is the most common genetic alteration encountered in the above entity?