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Case of the Week

2021-23/ June 7

Contributors:  Costantino Ricci and Michelangelo Fiorentino

A woman in her early 50s presented with a kidney mass, which had been incidentally identified during radiological exams performed for other clinical issues.

Click on the below thumbnails to enlarge photos.

5 photo(s) Updated on: June 03, 2021


1.  What is the correct diagnosis?

a. Low-grade oncocytic tumor (LOT)
b. High-grade oncocytic tumor (HOT)
c. Eosinophilic variant of chromophobe renal cell carcinoma (E-Chr-RCC)
d. Eosinophilic solid and cystic renal cell carcinoma (ESC-RCC)
e. Oncocytoma (O)

2. Which of the following immunohistochemical assays, when positive expression is present, supports the diagnosis?

a. CK20 and Cathepsin K
b. HMB45 and CD117
c. CK7 and CD117
d. CK20 and Melan A
e. Cathepsin K and ALK

3. What histological feature supports the diagnosis?

a. “Raisinoid” nuclei
b. “Stippling”
c. Nuclear pseudoinclusion
d. Chicken-wire vasculature
e. High mitotic index

About GUPS

The Genitourinary Pathology Society (GUPS) was formed with the vision of advancing the care of patients with urologic diseases through enhancements of best practices, research, and education in the subspecialty of Urological Pathology.

GUPS is an official Companion Society of the United States and Canadian Academy of Pathology (USCAP).



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