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Case of the Week

2021-30/July 26

Contributors:  Ruth Birbe, William Rafferty

A female patient in her mid-60s presents with an incidental 1.7 cm left kidney mass on CT. A robotic-assisted partial nephrectomy shows a well-circumscribed not encapsulated tan solid nodule with small cystic foci, confined to the kidney (stage pT1a)

Click on the below thumbnails to enlarge photos.

5 photo(s) Updated on: July 25, 2021


1.  What is the correct diagnosis?

a. Chromophobe renal cell carcinoma with squamous differentiation

b. Alveolar soft part sarcoma

c. Biphasic papillary renal cell carcinoma

d. Invasive urothelial carcinoma with squamous differentiation of the renal pelvis

e. Metanephric adenoma

2. What immunohistochemical stain profile is characteristic in this entity?

a. TFE3 +, MyoD1 +, PAS + diastase resistant

b. Cyclin D1 +, alpha methyl Co-A racemase +, CK7 +, CK-903 +, CD117-

c. P63 +, GATA3 +, uroplakin +, PAX8 -, high molecular weight keratin +

d. Vimentin –, CD117 +, e-cadherin +, CK7 +, hales colloidal iron +

e. WT1 +, CD57+, alpha methyl Co-A racemase -

About GUPS

The Genitourinary Pathology Society (GUPS) was formed with the vision of advancing the care of patients with urologic diseases through enhancements of best practices, research, and education in the subspecialty of Urological Pathology.

GUPS is an official Companion Society of the United States and Canadian Academy of Pathology (USCAP).



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