Contributors: Ruth Birbe, William Rafferty
A female patient in her mid-60s presents with an incidental 1.7 cm left kidney mass on CT. A robotic-assisted partial nephrectomy shows a well-circumscribed not encapsulated tan solid nodule with small cystic foci, confined to the kidney (stage pT1a)
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1. What is the correct diagnosis?
a. Chromophobe renal cell carcinoma with squamous differentiation
b. Alveolar soft part sarcoma
c. Biphasic papillary renal cell carcinoma
d. Invasive urothelial carcinoma with squamous differentiation of the renal pelvise. Metanephric adenoma
2. What immunohistochemical stain profile is characteristic in this entity?
a. TFE3 +, MyoD1 +, PAS + diastase resistant
b. Cyclin D1 +, alpha methyl Co-A racemase +, CK7 +, CK-903 +, CD117-
c. P63 +, GATA3 +, uroplakin +, PAX8 -, high molecular weight keratin +
d. Vimentin –, CD117 +, e-cadherin +, CK7 +, hales colloidal iron +
e. WT1 +, CD57+, alpha methyl Co-A racemase -