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Case of the Week

2021-39/ September 27

Contributors:  Jonathan Lee, William Lau, Reza Alaghehbandan

A man in his late 80s presented with urinary retention and a PSA of 2.2 ng/mL.  He underwent a TURP.  On cystoscopy, he was noted to have abnormal tissue at the base of the prostate that had a papillary appearance.

Click on the below thumbnails to enlarge photos.

5 photo(s) Updated on: September 25, 2021
  • GATA3
  • NKX3.1


1.  What is the correct diagnosis?

a)     High-grade papillary urothelial carcinoma

b)     High-grade prostatic adenocarcinoma with pseudopapillary features

c)     Metastatic colonic adenocarcinoma

d)     Metastatic solid-pseudopapillary carcinomas of the pancreas

About GUPS

The Genitourinary Pathology Society (GUPS) was formed with the vision of advancing the care of patients with urologic diseases through enhancements of best practices, research, and education in the subspecialty of Urological Pathology.

GUPS is an official Companion Society of the United States and Canadian Academy of Pathology (USCAP).



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