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Case of the Week

2021-40/October 4

Contributors:  Andrew Hall, Jasreman Dhillon

A 61 year old male developed a scrotal mass which on gross examination revealed a 2.8 x 2.1 x 1.5 cm soft, multilocular cystic mass with white-yellow semi-translucent gelatinous contents

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1.  What is the correct diagnosis?

a. Epithelioid mesothelioma

 b. Papillary serous carcinoma

 c. Yolk sac tumor

 d. Embryonal Carcinoma

 e. Adenocarcinoma of rete testis

2. What immunohistochemical stain results support this diagnosis?

a. SALL4-, CD30-, Calretinin+, WT1+

b. P16+, CEA+, Calretinin-, WT1+

c. SALL4+, AFP+, CDX2+, CD30-

d. SALL4+, CD30+, AFP-, CDX2-

e. PAX8+, MOC31+, SALL4-, CD30

3. What molecular test result supports this diagnosis?

a. BAP1 loss

b. MTAP retention

c. BRAF mutation

d. Isochrome 12p

e. CDK2NA amplification

About GUPS

The Genitourinary Pathology Society (GUPS) was formed with the vision of advancing the care of patients with urologic diseases through enhancements of best practices, research, and education in the subspecialty of Urological Pathology.

GUPS is an official Companion Society of the United States and Canadian Academy of Pathology (USCAP).



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