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Case of the Week

Editors: Francesca Khani  (Frk9007@med.cornell.edu) and Mahmut Akgul (akgulm@amc.edu)

2021-49/December 6

Contributors: Maria Estela Pompeu do Amaral, Daniel Athanazio 

A man in his 80s reported hematuria during preoperative period before prostatectomy due to prostate cancer. A 1.9 cm exophytic tumor was detected in bladder dome at cystoscopy. A multidisciplinary team opted for radical prostatectomy and partial cystectomy. The radical prostatectomy specimen showed a prostatic acinar adenocarcinoma Gleason score 4+3=7  (Grade Group 3 with cribriform morphology), pT3a. Images from the partial cystectomy are shown below.  

Click on the below thumbnails to enlarge photos.

5 photo(s) Updated on: December 04, 2021
  • Figure 1
  • Figure 2
  • Figure 3
  • Figure 4
  • Figure 5


1.  What is the correct diagnosis?      

a) Metastatic prostate adenocarcinoma

b) Urothelial carcinoma with clear cell morphology 

c) Mullerian-type clear cell adenocarcinoma

d) Collision tumor: urothelial carcinoma and metastatic renal cell carcinoma

e) Urothelial carcinoma with lipid-rich morphology

About GUPS

The Genitourinary Pathology Society (GUPS) was formed with the vision of advancing the care of patients with urologic diseases through enhancements of best practices, research, and education in the subspecialty of Urological Pathology.

GUPS is an official Companion Society of the United States and Canadian Academy of Pathology (USCAP).



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