Contributors: Maria Estela Pompeu do Amaral, Daniel Athanazio
A man in his 80s reported hematuria during preoperative period before prostatectomy due to prostate cancer. A 1.9 cm exophytic tumor was detected in bladder dome at cystoscopy. A multidisciplinary team opted for radical prostatectomy and partial cystectomy. The radical prostatectomy specimen showed a prostatic acinar adenocarcinoma Gleason score 4+3=7 (Grade Group 3 with cribriform morphology), pT3a. Images from the partial cystectomy are shown below.
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1. What is the correct diagnosis?
a) Metastatic prostate adenocarcinoma
b) Urothelial carcinoma with clear cell morphology
c) Mullerian-type clear cell adenocarcinoma
d) Collision tumor: urothelial carcinoma and metastatic renal cell carcinoma
e) Urothelial carcinoma with lipid-rich morphology