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Case of the Week

Editors: Francesca Khani  (Frk9007@med.cornell.edu) and Mahmut Akgul (akgulm@amc.edu)

2021-50/December 13

Contributors: Stephanie J Conrad, Hongzhi, Xu, Elizabeth Genega 

A woman in her 60s with a history of COPD, GERD and arthritis presented with a one week history of right flank pain. Work-up revealed an obstructed right kidney with a staghorn calculus and a cystic renal mass. Urine cultures grew E. coli and P. mirabilis.  

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1. What is the correct diagnosis?

     a. Clear cell renal cell carcinoma

     b. Xanthogranulomatous pyelonephritis  

     c. Mycobacterial infection

     d. Spindle cell neoplasm

     e. Malakoplakia 

2.  Which of the immunohistochemical stains, when positive, supports the diagnosis?

      a. CD68

      b. Acid Fast

      c. Pankeratin

      d. PAX-8

About GUPS

The Genitourinary Pathology Society (GUPS) was formed with the vision of advancing the care of patients with urologic diseases through enhancements of best practices, research, and education in the subspecialty of Urological Pathology.

GUPS is an official Companion Society of the United States and Canadian Academy of Pathology (USCAP).



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