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Case of the Week

Editor: Mahmut Akgul (akgulm@amc.edu)

2022-21/May 23

Contributors: Daniel Athanazio, Paulo Roberto Fontes Athanazio

A teenager noticed a nodule in the dorsal side of the penis two years before this presentation. The nodule was surveilled clinically. In this period, no skin lesions were noted. In the last months, the lesion rapidly grew causing ulceration in dorsal skin and invading corpora cavernosa and corpus spongiosum (as evaluated by imaging studies).

Click on the below thumbnails to enlarge photos.

5 photo(s) Updated on: May 20, 2022


1. What is the correct diagnosis?

a) Penile osteosarcoma

b) Sarcomatoid squamous cell carcinoma of the penis

c) Giant cell tumor of soft tissue

d) Melanoma with osteosarcomatous differentiation

e) Paraffinoma/Sclerosing lipogranuloma

f) Sarcomatoid urothelial carcinoma of the urethra

About GUPS

The Genitourinary Pathology Society (GUPS) was formed with the vision of advancing the care of patients with urologic diseases through enhancements of best practices, research, and education in the subspecialty of Urological Pathology.

GUPS is an official Companion Society of the United States and Canadian Academy of Pathology (USCAP).



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