Literature Watch & News: Genitourinary Pathology (October 2021)

Sounak Gupta, MBBS, PhD and Rohit Mehra, MD.

Kidney Cancer

Different Fumarate Hydratase Gene Variants Are Associated With Distinct Cancer Phenotypes.

JCO Precision Oncology. 2021(5):1568-1578.

https://ascopubs.org/doi/full/10.1200/PO.21.00263

Co-existence of ESC-RCC, EVT, and LOT as synchronous and metachronous tumors in six patients with multifocal neoplasia but without clinical features of tuberous sclerosis complex.

Hum Pathol. 2021 Oct;116:1-11. doi: 10.1016/j.humpath.2021.06.002. Epub 2021 Jun 19. PMID: 34153307.

https://pubmed.ncbi.nlm.nih.gov/34153307/

Eosinophilic vacuolated tumor (EVT) of kidney demonstrates sporadic TSC/MTOR mutations: next-generation sequencing multi-institutional study of 19 cases.

Mod Pathol. 2021 Sep 14. doi: 10.1038/s41379-021-00923-6. Epub ahead of print. Erratum in: Mod Pathol. 2021 Oct 5;: PMID: 34521993.

https://pubmed.ncbi.nlm.nih.gov/34521993/

Low-grade oncocytic renal tumor (LOT): mutations in mTOR pathway genes and low expression of FOXI1.

Mod Pathol. 2021 Sep 16. doi: 10.1038/s41379-021-00906-7. Epub ahead of print. PMID: 34531523.

https://pubmed.ncbi.nlm.nih.gov/34531523/

Germline and sporadic mTOR pathway mutations in low-grade oncocytic tumor of the kidney.

Mod Pathol. 2021 Sep 20. doi: 10.1038/s41379-021-00896-6. Epub ahead of print. PMID: 34538873.

https://pubmed.ncbi.nlm.nih.gov/34538873/

Papillary Renal Cell Carcinoma With Microcystic Architecture Is Strongly Associated With Extrarenal Invasion and Metastatic Disease,

The American Journal of Surgical Pathology: September 09, 2021. Epub ahead of print. doi: 10.1097/PAS.0000000000001802.

Prognostic Significance of Percentage Necrosis in Clear Cell Renal Cell Carcinoma: A Clinicopathologic Study of Factors Associated With Survival in Pakistani Patients,

American Journal of Clinical Pathology, 2021; doi: 10.1093/ajcp/aqab136.

Urinary Bladder Cancer

Utility of D2-40, Cytokeratin 5/6, and High-Molecular-weight Cytokeratin (Clone 34βE12) in Distinguishing Intraductal Spread of Urothelial Carcinoma From Prostatic Stromal Invasion.

Am J Surg Pathol. 2021 Sep 23. doi: 10.1097/PAS.0000000000001816. Epub ahead of print. PMID: 34560681.

https://pubmed.ncbi.nlm.nih.gov/34560681/

Upper urothelial tract High Grade Carcinoma: Comparison of Urine Cytology and DNA Methylation Analysis in Urinary Samples.

Hum Pathol. 2021 Sep 25:S0046-8177(21)00166-0. doi: 10.1016/j.humpath.2021.09.007. Epub ahead of print. PMID: 34582934.

https://pubmed.ncbi.nlm.nih.gov/34582934/

CD274 (PD-L1) Copy Number Changes (Gain) & Response to Immune Checkpoint Blockade Therapy in Carcinomas of the Urinary Tract.

Bladder Cancer. Jan. 2021: 1 – 6. doi: 10.3233/BLC-201532.

Reappraisal of HER2 Amplification in High-Grade Urothelial Carcinoma Based on 2018 ASCO/CAP Clinical Practice Guidelines.

Am J Clin Pathol. 2021 Jun 14:aqab083. doi: 10.1093/ajcp/aqab083. Epub ahead of print. PMID: 34124742.

https://pubmed.ncbi.nlm.nih.gov/34124742/

Prostate Cancer

Optimal Method for Reporting Prostate Cancer Grade in MRI-targeted Biopsies.

Am J Surg Pathol. 2021 Jun 10. doi: 10.1097/PAS.0000000000001758. Epub ahead of print. PMID: 34115670.

https://pubmed.ncbi.nlm.nih.gov/34115670/

Intraductal Adenocarcinoma of the Prostate With Cribriform or Papillary Ductal Morphology: Rare Biopsy Cases Lacking Associated Invasive High-grade Carcinoma.

Am J Surg Pathol. 2021 Oct 7. doi: 10.1097/PAS.0000000000001819. Epub ahead of print. PMID: 34619708.

https://pubmed.ncbi.nlm.nih.gov/34619708/

Diagnosis of "cribriform" prostatic adenocarcinoma: an interobserver reproducibility study among urologic pathologists with recommendations.

Am J Cancer Res. 2021 Aug 15;11(8):3990-4001. PMID: 34522463; PMCID: PMC8414383.

https://pubmed.ncbi.nlm.nih.gov/34522463/

Prognostic value of cribriform size, percentage, and intraductal carcinoma in Gleason Score 7 prostate cancer with Cribriform Gleason Pattern 4.

Hum Pathol. 2021 Sep 17:S0046-8177(21)00163-5. doi: 10.1016/j.humpath.2021.09.005. Epub ahead of print. PMID: 34543668.

https://pubmed.ncbi.nlm.nih.gov/34543668/

Testis Cancer

Somatic-type Malignancies in Testicular Germ Cell Tumors: A Clinicopathologic Study of 63 Cases.

Am J Surg Pathol. 2021 Aug 2. doi: 10.1097/PAS.0000000000001789. Epub ahead of print. PMID: 34334690.

https://pubmed.ncbi.nlm.nih.gov/34334690/

Testicular Germ-Cell Tumors with Spermatic Cord Involvement: A Retrospective International Multi-Institutional Experience.

Mod Pathol. 2021 Sep 9. doi: 10.1038/s41379-021-00912-9. Epub ahead of print. PMID: 34504308.

https://pubmed.ncbi.nlm.nih.gov/34504308/

Adenocarcinoma of the Rete Testis: Seven Additional Cases, Including Exclusively and Predominantly Intrarete Tumors.

Am J Surg Pathol. 2021 Jul 1. doi: 10.1097/PAS.0000000000001771. Epub ahead of print. PMID: 34224412.

https://pubmed.ncbi.nlm.nih.gov/34224412/

Nodular Maturation of the Testis,

The American Journal of Surgical Pathology: July 12, 2021. Epub ahead of print. doi: 10.1097/PAS.0000000000001775.

Penile Cancer

A comparative study of AJCC and the modified staging system in pT2/pT3 penile squamous cell carcinoma- A validation on an external dataset.

Histopathology. 2021 Sep 29. doi: 10.1111/his.14575. Epub ahead of print. PMID: 34586682.

https://pubmed.ncbi.nlm.nih.gov/34586682/

Adrenal Tumors

SMARCA4-Deficient Undifferentiated Tumor Diagnosed on Adrenal Sampling.

Am J Clin Pathol. 2021 Aug 31:aqab101. doi: 10.1093/ajcp/aqab101. Epub ahead of print. PMID: 34463317.

https://pubmed.ncbi.nlm.nih.gov/34463317/

TERT Copy Number Alterations, Promoter Mutations and Rearrangements in Adrenocortical Carcinomas.

Endocr Pathol. 2021 Sep 22. doi: 10.1007/s12022-021-09691-0. Epub ahead of print. PMID: 34549366.

https://pubmed.ncbi.nlm.nih.gov/34549366/

Artificial Intelligence and Genitourinary Cancers

Artificial Intelligence in Pathology.

Am J Pathol. 2021 Oct;191(10):1670-1672. doi: 10.1016/j.ajpath.2021.07.011. Epub 2021 Aug 13. PMID: 34391718.

https://pubmed.ncbi.nlm.nih.gov/34391718/

Validating Whole Slide Imaging Systems for Diagnostic Purposes in Pathology: Guideline Update From the College of American Pathologists in Collaboration With the American Society for Clinical Pathology and the Association for Pathology Informatics.

Arch Pathol Lab Med. 2021 May 18. doi: 10.5858/arpa.2020-0723-CP. Online ahead of print. PMID: 34003251.

https://pubmed.ncbi.nlm.nih.gov/34003251/