Literature Watch & News: Genitourinary Pathology (July 2021)

Sounak Gupta, MBBS, PhD and Rohit Mehra, MD.

Kidney Cancer

Improving Renal Tumor Biopsy Prognostication With BAP1 Analyses.

Kapur et al. Arch Pathol Lab Med (2021).

https://doi.org/10.5858/arpa.2020-0413-OA

EWSR1-PATZ1 fusion renal cell carcinoma: a recurrent gene fusion characterizing thyroid-like follicular renal cell carcinoma.

Al-Obaidy et al. Mod Pathol. 2021 Jun 7. doi: 10.1038/s41379-021-00833-7. Online ahead of print. PMID: 34099871

https://pubmed.ncbi.nlm.nih.gov/34099871/

A contemporary guide to chromosomal copy number profiling in the diagnosis of renal cell carcinoma.

Gupta et al. Urol Oncol. 2021 Jun 3:S1078-1439(21)00205-2. doi: 10.1016/j.urolonc.2021.04.042. Online ahead of print. PMID: 34092479

https://pubmed.ncbi.nlm.nih.gov/34092479/

Low-Grade Oncocytic Tumor of Kidney (CK7-Positive, CD117-Negative): Incidence in a single institutional experience with clinicopathological and molecular characteristics.

Kravtsov et al. Hum Pathol. 2021 May 4;114:9-18. doi: 10.1016/j.humpath.2021.04.013. Online ahead of print. PMID: 33961838

https://pubmed.ncbi.nlm.nih.gov/33961838/

Low-grade oncocytic tumour expands the spectrum of renal oncocytic tumours and deserves separate classification: a review of 23 cases from a single tertiary institute.

Akgul et al. J Clin Pathol. 2021 Jun 24:jclinpath-2021-207478. doi: 10.1136/jclinpath-2021-207478. Online ahead of print. PMID: 34168073

https://pubmed.ncbi.nlm.nih.gov/34168073/

SWI/SNF-deficient neoplasms of the genitourinary tract.

Sirohi et al. Semin Diagn Pathol. 2021 May;38(3):212-221. doi: 10.1053/j.semdp.2021.03.007. Epub 2021 Apr 3. PMID: 33840529

https://pubmed.ncbi.nlm.nih.gov/33840529/

Single-cell analyses of renal cell cancers reveal insights into tumor microenvironment, cell of origin, and therapy response.

Zhang et al. Proc Natl Acad Sci U S A. 2021 Jun 15;118(24):e2103240118. doi: 10.1073/pnas.2103240118. PMID: 34099557

https://pubmed.ncbi.nlm.nih.gov/34099557/

Dataset for the reporting of nephrectomy specimens for wilms’ tumour treated with preoperative chemotherapy: recommendations from the international society of paediatric oncology renal tumour study group.

Histopathology. 2021 May 3. PMID:  33942359

https://pubmed.ncbi.nlm.nih.gov/33942359/

TSC/MTOR mutated eosinophilic renal tumors are a distinct entity that are CK7+/CK20-/vimentin-: a validation study.

Hum Pathol. 2020 Dec 19;S0046-8177(20)30259-8. PMID:  33352195.

https://pubmed.ncbi.nlm.nih.gov/33352195/

Urinary Bladder Cancer

Molecular pathology of urothelial carcinoma.

Lopez-Beltran et al. Hum Pathol. 2021 Jul;113:67-83. doi: 10.1016/j.humpath.2021.04.001. Epub 2021 Apr 19. PMID: 33887300 Review.

https://pubmed.ncbi.nlm.nih.gov/33887300/

Urinary Large Cell Neuroendocrine Carcinoma: A Clinicopathologic Analysis of 22 Cases.

Wang et al. Am J Surg Pathol. 2021 Jun 2. doi: 10.1097/PAS.0000000000001740. Online ahead of print. PMID: 34074810

https://pubmed.ncbi.nlm.nih.gov/34074810/

Molecular subtypes of upper tract urothelial cancer: Setting the stage for precision therapy.

McConkey et al. Cancer Cell. 2021 Jun 14;39(6):745-747. doi: 10.1016/j.ccell.2021.05.004. PMID: 34129819

https://pubmed.ncbi.nlm.nih.gov/34129819/

Prostate Cancer

Advances in the selection of patients with prostate cancer for active surveillance.

Liu et al. Nat Rev Urol. 2021 Apr;18(4):197-208. doi: 10.1038/s41585-021-00432-w. Epub 2021 Feb 23. PMID: 33623103

https://pubmed.ncbi.nlm.nih.gov/33623103/

De novo neuroendocrine transdifferentiation in primary prostate cancer-a phenotype associated with advanced clinico-pathologic features and aggressive outcome.

Abdulfatah et al. Med Oncol. 2021 Feb 14;38(3):26. doi: 10.1007/s12032-021-01473-2. PMID: 33586037

https://pubmed.ncbi.nlm.nih.gov/33586037/

Clinical Utility of Subclassifying Positive Surgical Margins at Radical Prostatectomy.

Dason et al. BJU Int. 2021 Jun 23. doi: 10.1111/bju.15524. Online ahead of print. PMID: 34161656

https://pubmed.ncbi.nlm.nih.gov/34161656/

Association between BRCA2 alterations and intraductal and cribriform histologies in prostate cancer.

Lozano et al. Eur J Cancer. 2021 Apr;147:74-83. doi: 10.1016/j.ejca.2021.01.027. Epub 2021 Feb 21. PMID: 33626496

https://pubmed.ncbi.nlm.nih.gov/33626496/

Extent of High-Grade Prostatic Adenocarcinoma in Multiparametric Magnetic Resonance Imaging-Targeted Biopsy Enhances Prediction of Pathologic Stage.

Arch Pathol Lab Med. 2021 May 20. PMID:  34015819

https://pubmed.ncbi.nlm.nih.gov/34015819/

Testis Cancer

Circulating MicroRNAs, the Next-Generation Serum Biomarkers in Testicular Germ Cell Tumours: A Systematic Review.

Leao et al. Published:June 23, 2021DOI:https://doi.org/10.1016/j.eururo.2021.06.006

https://www.europeanurology.com/article/S0302-2838(21)01812-1/fulltext

Comparative molecular analysis of testicular Leydig cell tumors demonstrates distinct subsets of neoplasms with aggressive histopathologic features.

Rizzo et al. Mod Pathol. 2021 Jun 8. doi: 10.1038/s41379-021-00845-3. Online ahead of print. PMID: 34103665

https://pubmed.ncbi.nlm.nih.gov/34103665/

Discrepancy in pathology reports upon second review of radical orchiectomy specimens for testicular germ cell tumors.

Nason et al. Can Urol Assoc J. 2020 Dec;14(12):411-415. doi: 10.5489/cuaj.6481. PMID: 32574142

https://pubmed.ncbi.nlm.nih.gov/32574142/

SSX C-Terminus is a Useful Diagnostic Biomarker for Spermatocytic Tumour.

Anderson et al. Histopathology. 2021 May 7. doi: 10.1111/his.14398. Online ahead of print. PMID: 33963590

https://pubmed.ncbi.nlm.nih.gov/33963590/

Histologic Findings in Surgical Pathology Specimens From Individuals Taking Feminizing Hormone Therapy for the Purpose of Gender Transition: A Systematic Scoping Review.

Arch Pathol Lab Med. 2021 May 13. PMID:  33983412.

https://pubmed.ncbi.nlm.nih.gov/33983412/

Testicular Tumors: A Contemporary Update on Morphologic, Immunohistochemical and Molecular Features.

Adv Anat Pathol. 2021 Jul 1;28(4):258-275. PMID:  33871428

https://pubmed.ncbi.nlm.nih.gov/33871428/

Penile Cancer

What Is New in the Pathologic Staging of Penile Carcinoma in the 8th Edition of AJCC TNM Model: Rationale for Changes With Practical Stage-by-stage Category Diagnostic Considerations.

Adv Anat Pathol. 2021 Jul 1;28(4):209-227. PMID:  34050061 

https://pubmed.ncbi.nlm.nih.gov/34050061/

Genitourinary sarcoma

Clinicopathologic and molecular analysis of embryonal rhabdomyosarcoma of the genitourinary tract: evidence for a distinct DICER1-associated subgroup.

Mod Pathol. 2021 Apr 12. PMID:  33846547

https://pubmed.ncbi.nlm.nih.gov/33846547/

Artificial Intelligence and Genitourinary Cancers

Validating Whole Slide Imaging Systems for Diagnostic Purposes in Pathology: Guideline Update From the College of American Pathologists in Collaboration With the American Society for Clinical Pathology and the Association for Pathology Informatics. Evans et al.

Arch Pathol Lab Med. 2021 May 18. doi: 10.5858/arpa.2020-0723-CP. Online ahead of print. PMID: 34003251

https://pubmed.ncbi.nlm.nih.gov/34003251/

Computationally Derived Cribriform Area Index from Prostate Cancer Hematoxylin and Eosin Images Is Associated with Biochemical Recurrence Following Radical Prostatectomy and Is Most Prognostic in Gleason Grade Group 2.

Leo et al. Eur Urol Focus. 2021 Apr 30:S2405-4569(21)00122-X. doi: 10.1016/j.euf.2021.04.016. Online ahead of print. PMID: 33941504

https://pubmed.ncbi.nlm.nih.gov/33941504/