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Literature Watch & News: Genitourinary Pathology (January 2022)

Sounak Gupta, MBBS, PhD and Rohit Mehra, MD.

Kidney Cancer


Association of High-Intensity Exercise with Renal Medullary Carcinoma in Individuals with Sickle Cell Trait: Clinical Observations and Experimental Animal Studies.

Cancers (Basel). 2021 Nov 30;13(23):6022. PMID: 34885132; PMCID: PMC8656882.

https://pubmed.ncbi.nlm.nih.gov/34885132/


Papillary renal cell carcinoma: a single institutional study of 199 cases addressing classification, clinicopathologic and molecular features, and treatment outcome.

Mod Pathol. 2021 Dec 23. Epub ahead of print. PMID: 34949764.

https://pubmed.ncbi.nlm.nih.gov/34949764/


Expanding the clinicopathological spectrum of succinate dehydrogenase-deficient renal cell carcinoma with a focus on variant morphologies: a study of 62 new tumors in 59 patients.

Mod Pathol. 2021 Dec 23. Epub ahead of print. PMID: 34949766.

https://pubmed.ncbi.nlm.nih.gov/34949766/


Oncocytic renal neoplasms with diffuse keratin 7 immunohistochemistry harbor frequent alterations in the mammalian target of rapamycin pathway. Mod Pathol. 2021 Nov 20. Epub ahead of print. PMID: 34802045.

https://pubmed.ncbi.nlm.nih.gov/34802045/


Development and validation of a vascularity-based architectural classification for clear cell renal cell carcinoma: correlation with conventional pathological prognostic factors, gene expression patterns, and clinical outcomes.

Mod Pathol. 2021 Nov 30. Epub ahead of print. PMID: 34848832.

https://pubmed.ncbi.nlm.nih.gov/34848832/


Assessment of Risk of Hereditary Predisposition in Patients With Melanoma and/or Mesothelioma and Renal Neoplasia.

JAMA Netw Open. 2021 Nov 1;4(11):e2132615. PMID: 34767027; PMCID: PMC8590170.

https://pubmed.ncbi.nlm.nih.gov/34767027/


Renal Neoplasia in Polycystic Kidney Disease: An Assessment of Tuberous Sclerosis Complex-associated Renal Neoplasia and PKD1/TSC2 Contiguous Gene Deletion Syndrome.

Eur Urol. 2021 Dec 4:S0302-2838(21)02161-8. Epub ahead of print. PMID: 34876325.

https://pubmed.ncbi.nlm.nih.gov/34876325/


Renal Neoplasia in Hyperparathyroidism-Jaw Tumor Syndrome.

Mayo Clin Proc . 2021 Oct;96(10):2730-2731.  doi: 10.1016/j.mayocp.2021.08.011. PMID: 34607641

https://pubmed.ncbi.nlm.nih.gov/34607641/


Urinary Bladder Cancer


Different Responses to Neoadjuvant Chemotherapy in Urothelial Carcinoma Molecular Subtypes.

Eur Urol. 2021 Nov 12:S0302-2838(21)02138-2. Epub ahead of print. PMID: 34782206.

https://pubmed.ncbi.nlm.nih.gov/34782206/


International Bladder Cancer Group Consensus Statement on Clinical Trial Design for Patients with Bacillus Calmette-Guérin-exposed High-risk Non-muscle-invasive Bladder Cancer.

Eur Urol. 2021 Dec 23:S0302-2838(21)02213-2. Epub ahead of print. PMID: 34955291.

https://pubmed.ncbi.nlm.nih.gov/34955291/


Secondary malignancy after urologic reconstruction procedures: a multi-institutional case series.

Hum Pathol. 2021 Nov 19;119:69-78. Epub ahead of print. PMID: 34801602.

https://pubmed.ncbi.nlm.nih.gov/34801602/


TERT Promoter Mutations in Keratinizing and Nonkeratinizing Squamous Metaplasia of the Urinary Tract.

European Urology Open Science Volume 35, January 2022, Pages 74-78

https://www.sciencedirect.com/science/article/pii/S2666168321033851


Prostate Cancer


Targeting SWI/SNF ATPases in enhancer-addicted prostate cancer.

Nature. 2021 Dec 22. Epub ahead of print. PMID: 34937944.

https://pubmed.ncbi.nlm.nih.gov/34937944/


Defining the Impact of Family History on Detection of High-grade Prostate Cancer in a Large Multi-institutional Cohort.

Eur Urol. 2021 Dec 31. Epub ahead of print.

https://www.europeanurology.com/article/S0302-2838(21)02222-3/fulltext


High-intensity focused ultrasound for the treatment of prostate cancer: assessing location of failure after focal therapy in prostate cancer and review of histological characteristics and clinicopathologic correlates after treatment-a 5-year experience.

Hum Pathol. 2021 Nov 18;119:79-84. Epub ahead of print. PMID: 34801600.

https://pubmed.ncbi.nlm.nih.gov/34801600/


Prostatic Ductal Adenocarcinoma Controlled for Tumor Grade, Stage, and Margin Status Does Not Independently Influence the Likelihood of Biochemical Recurrence in Localized Prostate Cancer After Radical Prostatectomy.

Arch Pathol Lab Med. 2021 Nov 8. Epub ahead of print. PMID: 34739539.

https://pubmed.ncbi.nlm.nih.gov/34739539/


Variance of Tumor Grade at Radical Prostatectomy With Assessment of Each Tumor Nodule Versus Global Grading.

Arch Pathol Lab Med. 2021 Nov 9. Epub ahead of print. PMID: 34752602.

https://pubmed.ncbi.nlm.nih.gov/34752602/


    Testis Cancer


    Molecular assessment of testicular adult granulosa cell tumor demonstrates significant differences when compared to ovarian counterparts.

    Mod Pathol. 2021 Nov 29. Epub ahead of print. PMID: 34845303.
    https://pubmed.ncbi.nlm.nih.gov/34845303/


    Large Cell Calcifying Sertoli Cell Tumour: A Contemporary Multi-Institutional Case Series Highlighting the Diagnostic Utility of PRKAR1A Immunohistochemistry.

    Histopathology. 2021 Nov 15. Epub ahead of print. PMID: 34780072.
    https://pubmed.ncbi.nlm.nih.gov/34780072/


    Large Cell Calcifying Sertoli Cell Tumor: A Clinicopathologic Study of 18 Cases With Comprehensive Review of the Literature and Reappraisal of Prognostic Features.

    Am J Surg Pathol. 2021 Dec 16. Epub ahead of print. PMID: 34913878

    https://pubmed.ncbi.nlm.nih.gov/34913878/


    Penile Cancer


    Lichen Sclerosus et Atrophicus With Histopathologic Features Mimicking Mycosis Fungoides: A Large Series of Cases Comparing Genital With Extragenital Lichen Sclerosus.

    Am J Surg Pathol 2022 Jan 1;46(1):83-88.  doi: 10.1097/PAS.0000000000001738.PMID: 34049317 https://pubmed.ncbi.nlm.nih.gov/34049317/


    Digital Pathology/ Artificial Intelligence


    Real-time diagnosis and Gleason grading of prostate core needle biopsies using nonlinear microscopy.

    Mod Pathol. 2021 Nov 2:1–10. Epub ahead of print. PMID: 34725447; PMCID: PMC8560363.

    https://pubmed.ncbi.nlm.nih.gov/34725447/


    A Hybrid Human-Machine Learning Approach for Screening Prostate Biopsies Can Improve Clinical Efficiency Without Compromising Diagnostic Accuracy.

    Arch Pathol Lab Med. 2021 Sep 30. Epub ahead of print. PMID: 34591085.

    https://pubmed.ncbi.nlm.nih.gov/34591085/




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    The Genitourinary Pathology Society (GUPS) was formed with the vision of advancing the care of patients with urologic diseases through enhancements of best practices, research, and education in the subspecialty of Urological Pathology.

    GUPS is an official Companion Society of the United States and Canadian Academy of Pathology (USCAP).

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