Literature Watch & News: Genitourinary Pathology (January 2021)

Sounak Gupta, MBBS, PhD and Rohit Mehra, MD.

Kidney Cancer

Contemporary Characterization and Recategorization of Adult Unclassified Renal Cell Carcinoma. 

https://pubmed.ncbi.nlm.nih.gov/33239504/

Kwon et al. Am J Surg Pathol. 2020 Nov 24. Online ahead of print. PMID: 33239504 

Grading Chromophobe Renal Cell Carcinoma: Evidence for a Four-tiered Classification Incorporating Coagulative Tumor Necrosis. 

https://pubmed.ncbi.nlm.nih.gov/33172723/

Avulova et al. Eur Urol. 2020 Nov 7:S0302-2838(20)30784-3. doi: 10.1016/j.eururo.2020.10.007. Online ahead of print. PMID: 33172723

The Clinicopathologic and Molecular Landscape of Clear Cell Papillary Renal Cell Carcinoma: Implications in Diagnosis and Management.

https://pubmed.ncbi.nlm.nih.gov/33046271/

Weng et al. Eur Urol. 2020 Oct 9:S0302-2838(20)30719-3. doi: 10.1016/j.eururo.2020.09.027. Online ahead of print. PMID: 33046271

Systemic Therapies for the Management of Non–Clear Cell Renal Cell Carcinoma: What Works, What Doesn’t, and What the Future Holds.

https://www.clinical-genitourinary-cancer.com/article/S1558-7673(20)30266-4/fulltext

Zoumpourlis et al. Clinical Genitourinary Cancer. 2020 Dec; https://doi.org/10.1016/j.clgc.2020.11.005

Sarcomatoid renal cell carcinoma: biology, natural history and management.

https://www.nature.com/articles/s41585-020-00382-9

Blum et al. Nat Rev Urol. 2020 Dec;17(12):659-678.  doi: 10.1038/s41585-020-00382-9.  Epub 2020 Oct 13.

Urinary Bladder Cancer

Mesonephric (Wolffian-derived) Adenocarcinoma of the Female Urethra.

https://pubmed.ncbi.nlm.nih.gov/33284194/

Paner et al. Am J Surg Pathol. 2020 Dec 4. doi: 10.1097/PAS.0000000000001635. Online ahead of print. PMID: 33284194

Histopathologic Characterization of Bladder Perivascular Epithelioid Cell Neoplasms (PEComa). A Series of 11 Cases With a Subset Having TFE3 Rearrangements.

https://journals.lww.com/ajsp/Abstract/9000/Histopathologic_Characterization_of_Bladder.97340.asp

Neil et al. Am J Surg Pathol. 2020 Sep 29.  doi: 10.1097/PAS.0000000000001592.  Online ahead of print. 

Urothelial carcinoma in situ: diagnostic update.

https://pubmed.ncbi.nlm.nih.gov/33234229/

McKenney JK. Pathology. 2021 Jan;53(1):86-95. doi: 10.1016/j.pathol.2020.10.001. Epub 2020 Nov 21. PMID: 33234229

Nested Variant of Urothelial Carcinoma Is a Luminal Bladder Tumor With Distinct Coexpression of the Basal Marker Cytokeratin 5/6.

https://pubmed.ncbi.nlm.nih.gov/33118597/

Johnson et al. Am J Clin Pathol. 2020 Oct 29:aqaa160. doi: 10.1093/ajcp/aqaa160. Online ahead of print. PMID: 33118597

Prostate Cancer

Molecular Biomarker Testing in Localized Prostate Cancer: The Critical Role of Pathologists.

https://pubmed.ncbi.nlm.nih.gov/33351911/

Baraban et al. Arch Pathol Lab Med. 2020 Dec 22. doi: 10.5858/arpa.2020-0641-ED. Online ahead of print. PMID: 33351911

Similarities and Differences in the 2019 ISUP and GUPS Recommendations on Prostate Cancer Grading: A Guide for Practicing Pathologists.

https://pubmed.ncbi.nlm.nih.gov/33027069/

Smith SC et al. Adv Anat Pathol. 2021 Jan;28(1):1-7. doi: 10.1097/PAP.0000000000000287. PMID: 33027069

Genomic and phenotypic heterogeneity in prostate cancer.

https://pubmed.ncbi.nlm.nih.gov/33328650/

Haffner et al. Nat Rev Urol. 2020 Dec 16. doi: 10.1038/s41585-020-00400-w. Online ahead of print. PMID: 33328650

Clinical deployment of AI for prostate cancer diagnosis.

https://pubmed.ncbi.nlm.nih.gov/33328042/

Janowczyk et al. Lancet Digit Health. 2020 Aug;2(8):e383-e384. doi: 10.1016/S2589-7500(20)30163-1. PMID: 33328042

Impact of Lineage Plasticity to and from a Neuroendocrine Phenotype on Progression and Response in Prostate and Lung Cancers.

https://pubmed.ncbi.nlm.nih.gov/33217316/

Rubin et al. Mol Cell. 2020 Nov 19;80(4):562-577. doi: 10.1016/j.molcel.2020.10.033. PMID: 33217316

Testis Cancer

Pathological predictors of metastatic disease in testicular non-seminomatous germ cell tumors: which tumor-node-metastasis staging system?

https://www.nature.com/articles/s41379-020-00717-2

Scandura et al. Mod Pathol. 2020 Dec 15.  doi: 10.1038/s41379-020-00717-2.  Online ahead of print. 

Immunophenotypic Characterization of Germ Cell Tumor–Derived Primitive Neuroectodermal Tumors: Evidence for Frequent Neuronal and/or Glial Differentiation

https://meridian.allenpress.com/aplm/article/doi/10.5858/arpa.2020-0352-OA/449248/Immunophenotypic-Characterization-of-Germ-Cell

Magers et al. Arch Pathol Lab Med. 2020 Dec 8.  doi: 10.5858/arpa.2020-0352-OA.  Online ahead of print. 

Germ Cell Tumor Molecular Heterogeneity Revealed Through Analysis of Primary and Metastasis Pairs.

https://pubmed.ncbi.nlm.nih.gov/33163850/

Cheng et al. JCO Precis Oncol. 2020 Oct 30;4:PO.20.00166. doi: 10.1200/PO.20.00166. eCollection 2020. PMID: 33163850

Vasculogenic Mesenchymal Tumor: A Clinicopathologic and Molecular Study of 55 Cases of a Distinctive Neoplasm Originating From Mediastinal Yolk Sac Tumor and an Occasional Precursor to Angiosarcoma.

https://pubmed.ncbi.nlm.nih.gov/33136584/

Levy et al. Am J Surg Pathol. 2020 Oct 30. doi: 10.1097/PAS.0000000000001615. Online ahead of print. PMID: 33136584

Characterisation of testicular function and spermatogenesis in transgender women.

https://pubmed.ncbi.nlm.nih.gov/33257947/

Vereecke et al. Hum Reprod. 2020 Nov 30:deaa254. doi: 10.1093/humrep/deaa254. Online ahead of print. PMID: 33257947

Penile Cancer

Nodular secondary syphilis in three HIV-positive patients: a case series.

https://pubmed.ncbi.nlm.nih.gov/32693735/

Wang et al. Int J STD AIDS. 2020 Sep;31(10):1004-1007. doi: 10.1177/0956462420933787. Epub 2020 Jul 21. PMID: 32693735

Current management and future perspectives of penile cancer: An updated review.

https://pubmed.ncbi.nlm.nih.gov/32799062/

Peyraud et al. Cancer Treat Rev. 2020 Nov;90:102087. doi: 10.1016/j.ctrv.2020.102087. Epub 2020 Aug 7. PMID: 32799062

COVID-19

Targeting transcriptional regulation of SARS-CoV-2 entry factors ACE2 and TMPRSS2.

https://pubmed.ncbi.nlm.nih.gov/33310900/

Qiao et al. Proc Natl Acad Sci U S A. 2020 Dec 11:202021450. doi: 10.1073/pnas.2021450118. Online ahead of print. PMID: 33310900