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Literature Watch & News: Genitourinary Pathology (January 2021)

Sounak Gupta, MBBS, PhD and Rohit Mehra, MD.

Kidney Cancer

Contemporary Characterization and Recategorization of Adult Unclassified Renal Cell Carcinoma. 


Kwon et al. Am J Surg Pathol. 2020 Nov 24. Online ahead of print. PMID: 33239504 

Grading Chromophobe Renal Cell Carcinoma: Evidence for a Four-tiered Classification Incorporating Coagulative Tumor Necrosis. 


Avulova et al. Eur Urol. 2020 Nov 7:S0302-2838(20)30784-3. doi: 10.1016/j.eururo.2020.10.007. Online ahead of print. PMID: 33172723

The Clinicopathologic and Molecular Landscape of Clear Cell Papillary Renal Cell Carcinoma: Implications in Diagnosis and Management.


Weng et al. Eur Urol. 2020 Oct 9:S0302-2838(20)30719-3. doi: 10.1016/j.eururo.2020.09.027. Online ahead of print. PMID: 33046271

Systemic Therapies for the Management of Non–Clear Cell Renal Cell Carcinoma: What Works, What Doesn’t, and What the Future Holds.


Zoumpourlis et al. Clinical Genitourinary Cancer. 2020 Dec; https://doi.org/10.1016/j.clgc.2020.11.005

Sarcomatoid renal cell carcinoma: biology, natural history and management.


Blum et al. Nat Rev Urol. 2020 Dec;17(12):659-678.  doi: 10.1038/s41585-020-00382-9.  Epub 2020 Oct 13.

Urinary Bladder Cancer

Mesonephric (Wolffian-derived) Adenocarcinoma of the Female Urethra.


Paner et al. Am J Surg Pathol. 2020 Dec 4. doi: 10.1097/PAS.0000000000001635. Online ahead of print. PMID: 33284194

Histopathologic Characterization of Bladder Perivascular Epithelioid Cell Neoplasms (PEComa). A Series of 11 Cases With a Subset Having TFE3 Rearrangements.


Neil et al. Am J Surg Pathol. 2020 Sep 29.  doi: 10.1097/PAS.0000000000001592.  Online ahead of print. 

Urothelial carcinoma in situ: diagnostic update.


McKenney JK. Pathology. 2021 Jan;53(1):86-95. doi: 10.1016/j.pathol.2020.10.001. Epub 2020 Nov 21. PMID: 33234229

Nested Variant of Urothelial Carcinoma Is a Luminal Bladder Tumor With Distinct Coexpression of the Basal Marker Cytokeratin 5/6.


Johnson et al. Am J Clin Pathol. 2020 Oct 29:aqaa160. doi: 10.1093/ajcp/aqaa160. Online ahead of print. PMID: 33118597

Prostate Cancer

Molecular Biomarker Testing in Localized Prostate Cancer: The Critical Role of Pathologists.


Baraban et al. Arch Pathol Lab Med. 2020 Dec 22. doi: 10.5858/arpa.2020-0641-ED. Online ahead of print. PMID: 33351911

Similarities and Differences in the 2019 ISUP and GUPS Recommendations on Prostate Cancer Grading: A Guide for Practicing Pathologists.


Smith SC et al. Adv Anat Pathol. 2021 Jan;28(1):1-7. doi: 10.1097/PAP.0000000000000287. PMID: 33027069

Genomic and phenotypic heterogeneity in prostate cancer.


Haffner et al. Nat Rev Urol. 2020 Dec 16. doi: 10.1038/s41585-020-00400-w. Online ahead of print. PMID: 33328650

Clinical deployment of AI for prostate cancer diagnosis.


Janowczyk et al. Lancet Digit Health. 2020 Aug;2(8):e383-e384. doi: 10.1016/S2589-7500(20)30163-1. PMID: 33328042

Impact of Lineage Plasticity to and from a Neuroendocrine Phenotype on Progression and Response in Prostate and Lung Cancers.


Rubin et al. Mol Cell. 2020 Nov 19;80(4):562-577. doi: 10.1016/j.molcel.2020.10.033. PMID: 33217316

    Testis Cancer

    Pathological predictors of metastatic disease in testicular non-seminomatous germ cell tumors: which tumor-node-metastasis staging system?


    Scandura et al. Mod Pathol. 2020 Dec 15.  doi: 10.1038/s41379-020-00717-2.  Online ahead of print. 

    Immunophenotypic Characterization of Germ Cell Tumor–Derived Primitive Neuroectodermal Tumors: Evidence for Frequent Neuronal and/or Glial Differentiation


    Magers et al. Arch Pathol Lab Med. 2020 Dec 8.  doi: 10.5858/arpa.2020-0352-OA.  Online ahead of print. 

    Germ Cell Tumor Molecular Heterogeneity Revealed Through Analysis of Primary and Metastasis Pairs.


    Cheng et al. JCO Precis Oncol. 2020 Oct 30;4:PO.20.00166. doi: 10.1200/PO.20.00166. eCollection 2020. PMID: 33163850

    Vasculogenic Mesenchymal Tumor: A Clinicopathologic and Molecular Study of 55 Cases of a Distinctive Neoplasm Originating From Mediastinal Yolk Sac Tumor and an Occasional Precursor to Angiosarcoma.


    Levy et al. Am J Surg Pathol. 2020 Oct 30. doi: 10.1097/PAS.0000000000001615. Online ahead of print. PMID: 33136584

    Characterisation of testicular function and spermatogenesis in transgender women.


    Vereecke et al. Hum Reprod. 2020 Nov 30:deaa254. doi: 10.1093/humrep/deaa254. Online ahead of print. PMID: 33257947

    Penile Cancer

    Nodular secondary syphilis in three HIV-positive patients: a case series.


    Wang et al. Int J STD AIDS. 2020 Sep;31(10):1004-1007. doi: 10.1177/0956462420933787. Epub 2020 Jul 21. PMID: 32693735

    Current management and future perspectives of penile cancer: An updated review.


    Peyraud et al. Cancer Treat Rev. 2020 Nov;90:102087. doi: 10.1016/j.ctrv.2020.102087. Epub 2020 Aug 7. PMID: 32799062


    Targeting transcriptional regulation of SARS-CoV-2 entry factors ACE2 and TMPRSS2.


    Qiao et al. Proc Natl Acad Sci U S A. 2020 Dec 11:202021450. doi: 10.1073/pnas.2021450118. Online ahead of print. PMID: 33310900

    About GUPS

    The Genitourinary Pathology Society (GUPS) was formed with the vision of advancing the care of patients with urologic diseases through enhancements of best practices, research, and education in the subspecialty of Urological Pathology.

    GUPS is an official Companion Society of the United States and Canadian Academy of Pathology (USCAP).



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