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Literature Watch & News: Genitourinary Pathology (April 2021)

Sounak Gupta, MBBS, PhD and Rohit Mehra, MD.

Kidney Cancer

TRIM63 is a sensitive and specific biomarker for MiT family aberration-associated renal cell carcinoma.

Wang XM et al. Mod Pathol. 2021. [Online ahead of print]


Integrative molecular characterization of sarcomatoid and rhabdoid renal cell carcinoma.

Bakouny Z et al. Nat Commun. 2021 Feb 5;12(1):808.


Distal Tubular Hyperplasia: A Proposal for a Unique Form of Renal Tubular Proliferation Distinct From Papillary Adenoma.

Williamson SR et al. Am J Surg Pathol. 2021 Apr 1;45(4):516-522.


Renal Neoplasia in Tuberous Sclerosis: A Study of 41 Patients.

Gupta S et al. Mayo Clin Proc. 2021 Jan 29 [Online ahead of print; PMID: 33526281]


TSC/MTOR mutated eosinophilic renal tumors are a distinct entity that are CK7+/CK20-/vimentin-: a validation study.

Tjota MY et al. Hum Pathol. 2020 Dec 19;S0046-8177(20)30259-8.


KANK1-NTRK3 fusions define a subset of BRAF mutation negative renal metanephric adenomas.

Catic A et al. BMC Med Genet. 2020 Oct 12;21(1):202.


Diagnostic approach in TFE3-rearranged renal cell carcinoma: a multi-institutional international survey.

Akgul M et al. J Clin Pathol. 2021 Jan 29:jclinpath-2020-207372. [Online ahead of print; PMID: 33514585]


Urinary Bladder Cancer

International Society of Urological Pathology Expert Opinion on Grading of Urothelial Carcinoma.

van der Kwast T et al. Eur Urol Focus. 2021 Mar 23. [Online ahead of print; PMID: 33771477]


Telomerase reverse transcriptase (TERT) promoter mutations in primary adenocarcinoma of bladder and urothelial carcinoma with glandular differentiation: pathogenesis and diagnostic implications.

Cheng L et al. Mod Pathol. 2021 Mar 5. [Online ahead of print; PMID: 33674765]


A Pan-Cancer Study of Somatic TERT Promoter Mutations and Amplification in 30,773 Tumors Profiled by Clinical Genomic Sequencing.

Gupta S et al. J Mol Diagn. 2021 Feb;23(2):253-263.


Plasma cell neoplasms of the bladder: a series of 9 cases.

Gupta R et al. Hum Pathol. 2021 Feb 24. [Online ahead of print; PMID: 33639141]


Prostate Cancer

A Comparison of Genitourinary Pathology Society (GUPS) and International Society of Urological Pathology (ISUP) Prostate Cancer Grading Guidelines.

Epstein JI, Hirsch MS. Am J Surg Pathol. 2021 Jan 19. [Online ahead of print; PMID: 33481386].


Homologous recombination deficiency (HRD) score in germline BRCA2- versus ATM-altered prostate cancer.

Lotan TL et al. Mod Pathol. 2021 Jan 18. [Online ahead of print; PMID: 33462368].


    Testis Cancer

    Immunohistochemical Characterization of 120 Testicular Sex Cord-Stromal Tumors With an Emphasis on the Diagnostic Utility of SOX9, FOXL2, and SF-1.

    Lau H et al. Am J Surg Pathol. 2021 Mar 22. [Online ahead of print].


    Assessment of Isochromosome 12p & 12p Abnormalities in Germ Cell Tumors Using FISH, SNP-Arrays & NGS/ Mate-Pair Sequencing.

    Freitag CE et al. Hum Pathol. 2021 Mar 30 [Online ahead of print; PMID: 33798590]


    “Embryonic-type Neuroectodermal Tumor” Should Replace “Primitive Neuroectodermal Tumor” of the Testis and Gynecologic Tract. A Rationale for New Nomenclature.

    Flood TA et al. Am J Surg Pathol. 2021 Mar 22. [Online ahead of print].


    Adrenal Cancer

    What Did We Learn from the Molecular Biology of Adrenal Cortical Neoplasia? From Histopathology to Translational Genomics.

    Juhlin CC et al. Endocr Pathol. 2021 Mar;32(1):102-133.


    About GUPS

    The Genitourinary Pathology Society (GUPS) was formed with the vision of advancing the care of patients with urologic diseases through enhancements of best practices, research, and education in the subspecialty of Urological Pathology.

    GUPS is an official Companion Society of the United States and Canadian Academy of Pathology (USCAP).



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