Literature Watch & News: Genitourinary Pathology (April 2021)

Sounak Gupta, MBBS, PhD and Rohit Mehra, MD.

Kidney Cancer

TRIM63 is a sensitive and specific biomarker for MiT family aberration-associated renal cell carcinoma.

Wang XM et al. Mod Pathol. 2021. [Online ahead of print]

https://www.nature.com/articles/s41379-021-00803-z

Integrative molecular characterization of sarcomatoid and rhabdoid renal cell carcinoma.

Bakouny Z et al. Nat Commun. 2021 Feb 5;12(1):808.

https://pubmed.ncbi.nlm.nih.gov/33547292/

Distal Tubular Hyperplasia: A Proposal for a Unique Form of Renal Tubular Proliferation Distinct From Papillary Adenoma.

Williamson SR et al. Am J Surg Pathol. 2021 Apr 1;45(4):516-522.

https://pubmed.ncbi.nlm.nih.gov/33560656/

Renal Neoplasia in Tuberous Sclerosis: A Study of 41 Patients.

Gupta S et al. Mayo Clin Proc. 2021 Jan 29 [Online ahead of print; PMID: 33526281]

https://pubmed.ncbi.nlm.nih.gov/33526281/

TSC/MTOR mutated eosinophilic renal tumors are a distinct entity that are CK7+/CK20-/vimentin-: a validation study.

Tjota MY et al. Hum Pathol. 2020 Dec 19;S0046-8177(20)30259-8.

https://pubmed.ncbi.nlm.nih.gov/33352195/

KANK1-NTRK3 fusions define a subset of BRAF mutation negative renal metanephric adenomas.

Catic A et al. BMC Med Genet. 2020 Oct 12;21(1):202.

https://pubmed.ncbi.nlm.nih.gov/33046021/

Diagnostic approach in TFE3-rearranged renal cell carcinoma: a multi-institutional international survey.

Akgul M et al. J Clin Pathol. 2021 Jan 29:jclinpath-2020-207372. [Online ahead of print; PMID: 33514585]

https://pubmed.ncbi.nlm.nih.gov/33514585/

Urinary Bladder Cancer

International Society of Urological Pathology Expert Opinion on Grading of Urothelial Carcinoma.

van der Kwast T et al. Eur Urol Focus. 2021 Mar 23. [Online ahead of print; PMID: 33771477]

https://pubmed.ncbi.nlm.nih.gov/33771477/

Telomerase reverse transcriptase (TERT) promoter mutations in primary adenocarcinoma of bladder and urothelial carcinoma with glandular differentiation: pathogenesis and diagnostic implications.

Cheng L et al. Mod Pathol. 2021 Mar 5. [Online ahead of print; PMID: 33674765]

https://pubmed.ncbi.nlm.nih.gov/33674765/

A Pan-Cancer Study of Somatic TERT Promoter Mutations and Amplification in 30,773 Tumors Profiled by Clinical Genomic Sequencing.

Gupta S et al. J Mol Diagn. 2021 Feb;23(2):253-263.

https://pubmed.ncbi.nlm.nih.gov/33285287/

Plasma cell neoplasms of the bladder: a series of 9 cases.

Gupta R et al. Hum Pathol. 2021 Feb 24. [Online ahead of print; PMID: 33639141]

https://pubmed.ncbi.nlm.nih.gov/33639141/

Prostate Cancer

A Comparison of Genitourinary Pathology Society (GUPS) and International Society of Urological Pathology (ISUP) Prostate Cancer Grading Guidelines.

Epstein JI, Hirsch MS. Am J Surg Pathol. 2021 Jan 19. [Online ahead of print; PMID: 33481386].

https://pubmed.ncbi.nlm.nih.gov/33481386/

Homologous recombination deficiency (HRD) score in germline BRCA2- versus ATM-altered prostate cancer.

Lotan TL et al. Mod Pathol. 2021 Jan 18. [Online ahead of print; PMID: 33462368].

https://pubmed.ncbi.nlm.nih.gov/33462368/

Testis Cancer

Immunohistochemical Characterization of 120 Testicular Sex Cord-Stromal Tumors With an Emphasis on the Diagnostic Utility of SOX9, FOXL2, and SF-1.

Lau H et al. Am J Surg Pathol. 2021 Mar 22. [Online ahead of print].

https://journals.lww.com/ajsp/Abstract/9000/Immunohistochemical_Characterization_of_120.97234.aspx

Assessment of Isochromosome 12p & 12p Abnormalities in Germ Cell Tumors Using FISH, SNP-Arrays & NGS/ Mate-Pair Sequencing.

Freitag CE et al. Hum Pathol. 2021 Mar 30 [Online ahead of print; PMID: 33798590]

https://pubmed.ncbi.nlm.nih.gov/33798590/

“Embryonic-type Neuroectodermal Tumor” Should Replace “Primitive Neuroectodermal Tumor” of the Testis and Gynecologic Tract. A Rationale for New Nomenclature.

Flood TA et al. Am J Surg Pathol. 2021 Mar 22. [Online ahead of print].

https://journals.lww.com/ajsp/Citation/9000/_Embryonic_type_Neuroectodermal_Tumor__Should.97232.aspx

Adrenal Cancer

What Did We Learn from the Molecular Biology of Adrenal Cortical Neoplasia? From Histopathology to Translational Genomics.

Juhlin CC et al. Endocr Pathol. 2021 Mar;32(1):102-133.

https://pubmed.ncbi.nlm.nih.gov/33534120/