Literature Watch & News: Genitourinary Pathology (April 2022)

Sounak Gupta, MBBS, PhD and Rohit Mehra, MD.

Kidney Cancer

NF2-mutated Renal Carcinomas Have Common Morphologic Features Which Overlap With Biphasic Hyalinizing Psammomatous Renal Cell Carcinoma: A Comprehensive Study of 14 Cases.

Am J Surg Pathol. 2022 Jan 17. Epub ahead of print. PMID: 35034039.

https://pubmed.ncbi.nlm.nih.gov/35034039/

Adult Wilms Tumor: Genetic Evidence of Origin of a Subset of Cases From Metanephric Adenoma.

Am J Surg Pathol. 2022 Feb 21. Epub ahead of print. PMID: 35184066.

https://pubmed.ncbi.nlm.nih.gov/35184066/

Do we need an updated classification of oncocytic renal tumors? : Emergence of low-grade oncocytic tumor (LOT) and eosinophilic vacuolated tumor (EVT) as novel renal entities.

Mod Pathol. 2022 Mar 10. Epub ahead of print. PMID: 35273336.

https://pubmed.ncbi.nlm.nih.gov/35273336/

Renal cell carcinoma associated with tuberous sclerosis complex (TSC)/mammalian target of rapamycin (MTOR) genetic alterations.

Mod Pathol. 2022 Mar;35(3):296-297. Epub 2022 Jan 19. PMID: 35046523.

https://pubmed.ncbi.nlm.nih.gov/35046523/

Clinicopathological and molecular characterization of biphasic hyalinizing psammomatous renal cell carcinoma: further support for the newly proposed entity.

Hum Pathol. 2022 Feb 19:S0046-8177(22)00039-9. Epub ahead of print. PMID: 35192800.

https://pubmed.ncbi.nlm.nih.gov/35192800/

Renal cell carcinoma in children and adolescents: a retrospective study of a French-Italian series of 93 cases.

Histopathology. 2022 Mar 3. Epub ahead of print. PMID: 35238063.

https://pubmed.ncbi.nlm.nih.gov/35238063/

Pathology of Wilms' tumour in International Society of Paediatric Oncology (SIOP) and Children's oncology group (COG) renal tumour studies: Similarities and differences.

Histopathology. 2022 Mar 11. Epub ahead of print. PMID: 35275409.

https://pubmed.ncbi.nlm.nih.gov/35275409/

Granulomas associated with renal neoplasms: A multi-institutional clinicopathological study of 111 cases.

Histopathology. 2022 Mar 29. Epub ahead of print. PMID: 35347739.

https://pubmed.ncbi.nlm.nih.gov/35347739/

A Clinicopathological and Molecular Analysis of Fumarate Hydratase (FH)-deficient Renal Cell Carcinomas with Heterogeneous Loss of FH Expression.

Int J Surg Pathol. 2022 Jan 20:10668969221074600. Epub ahead of print. PMID: 35048731.

https://pubmed.ncbi.nlm.nih.gov/35048731/

Urinary Bladder Cancer

p53 null phenotype is a "positive result" in urothelial carcinoma in situ.

Mod Pathol. 2022 Mar 23. Epub ahead of print. PMID: 35322193.

https://pubmed.ncbi.nlm.nih.gov/35322193/

Molecular pathology of the non-luminal Ba/Sq-like and Sc/NE-like classes of urothelial tumours: An integrated immunohistochemical analysis. Hum Pathol.

2022 Jan 31;122:11-24. Epub ahead of print. PMID: 35108518.

https://pubmed.ncbi.nlm.nih.gov/35108518/

Reclassifying pT3 renal pelvic urothelial carcinoma with renal parenchyma invasion to pT2 improves correlation with overall survival.

Hum Pathol. 2022 Mar 17:S0046-8177(22)00065-X. Epub ahead of print. PMID: 35307402.

https://pubmed.ncbi.nlm.nih.gov/35307402/

MYC Amplification in Epithelioid Angiosarcoma of the Urinary Bladder and Prostate Following Prostate Radiotherapy: A Case Report with a Novel Molecular Alteration.

Int J Surg Pathol. 2022 Feb 21:10668969221081740. Epub ahead of print. PMID: 35188832.

https://pubmed.ncbi.nlm.nih.gov/35188832/

Muscle-invasive Bladder Cancer Arising After Prostate Radiotherapy: A Rare Entity with Unique Genomic Features.

Eur Urol. 2022 Jan 30:S0302-2838(22)00067-7. Epub ahead of print. PMID: 35109971.

https://pubmed.ncbi.nlm.nih.gov/35109971/

Prostate Cancer

Analysis of separate training and validation radical prostatectomy cohorts identifies 0.25 mm diameter as an optimal definition for "large" cribriform prostatic adenocarcinoma.

Mod Pathol. 2022 Feb 10. Epub ahead of print. PMID: 35145197.

https://pubmed.ncbi.nlm.nih.gov/35145197/

Risk Stratification of Prostatic Adenocarcinoma Metastatic to the Lymph Nodes. Arch Pathol Lab Med.

2022 Feb 10. Epub ahead of print. PMID: 35142822.

https://pubmed.ncbi.nlm.nih.gov/35142822/

The Clinical Impact of pT3a Lesions in Patients With pT3b Prostate Cancer Undergoing Radical Prostatectomy.

Arch Pathol Lab Med. 2022 Jan 3Epub ahead of print. PMID: 34979562.

https://pubmed.ncbi.nlm.nih.gov/34979562/

A Rare Germline HOXB13 Variant Contributes to Risk of Prostate Cancer in Men of African Ancestry.

Eur Urol. 2022 Jan 11:S0302-2838(21)02271-5. Epub ahead of print. PMID: 35031163.

https://pubmed.ncbi.nlm.nih.gov/35031163/

The Needle in the Haystack: The Presence of Castrate-resistant Prostate Cancer Cells in Hormone-naïve Prostate Cancer.

Eur Urol. 2022 Feb 24:S0302-2838(22)01609-8. Epub ahead of print. PMID: 35221165.

https://pubmed.ncbi.nlm.nih.gov/35221165/

Pre-existing Castration-resistant Prostate Cancer-like Cells in Primary Prostate Cancer Promote Resistance to Hormonal Therapy.

Eur Urol. 2022 Jan 17:S0302-2838(22)00001-X. Epub ahead of print. PMID: 35058087.

https://pubmed.ncbi.nlm.nih.gov/35058087/

Radical Prostatectomy Without Biopsy: Audacious, Imprudent, or Innovative?

Eur Urol. 2022 Mar 25:S0302-2838(22)01679-7. Epub ahead of print. PMID: 35346513.

https://pubmed.ncbi.nlm.nih.gov/35346513/

Testis Cancer

Sarcomatoid Yolk Sac Tumor Harbors Somatic Mutations That Are Otherwise Rare in Testicular Germ Cell Tumors.

Am J Surg Pathol. 2022 Jan 17. Epub ahead of print. PMID: 35034041.

https://pubmed.ncbi.nlm.nih.gov/35034041/

Cytogenetics of Spermatocytic Tumors with a Discussion of Gain of Chromosome 12p in “Anaplastic Variants”.

Hum Pathol. 2022 April1. Epub ahead of print.

https://www.sciencedirect.com/science/article/pii/S0046817722000788

Penile Cancer

HPV-negative Penile Intraepithelial Neoplasia (PeIN) With Basaloid Features.

Am J Surg Pathol. 2022 Mar 17. Epub ahead of print. PMID: 35297786.

https://pubmed.ncbi.nlm.nih.gov/35297786/

Pathological characterization and clinical outcome of penile intraepithelial neoplasia variants: a North American series.

Mod Pathol. 2022 Feb 21. Epub ahead of print. PMID: 35190664.

https://pubmed.ncbi.nlm.nih.gov/35190664/

Soft Tissue Tumors of the Genitourinary Tract

Clinicopathologic Features of Scrotal Leiomyosarcoma: Single Institutional Experience of Ten Cases.

Hum Pathol. 2022 April1. Epub ahead of print.

https://www.sciencedirect.com/science/article/pii/S0046817722000776