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 Literature Watch & News: Genitourinary Pathology (2020 Q1)

Sounak Gupta, MBBS, PhD and Rohit Mehra, MD

Renal Cancer

  • Recurrent KRAS mutations in papillary renal neoplasm with reverse polarity. Al-Obaidy KI et al. Modern Pathology. 2019 Sep 18. PMID: 31534204. https://www.ncbi.nlm.nih.gov/pubmed/31534204 - This study, senior authored by the late Dr. David Grignon, a giant in the field of genitourinary pathology, is another seminal work which characterizes the morphologic features and molecular underpinnings of a unique variant of papillary renal cell carcinoma.                                                                                                                               
  • "Renal Cell Carcinoma With Leiomyomatous Stroma" Harbor Somatic Mutations of TSC1, TSC2, MTOR, and/or ELOC (TCEB1): Clinicopathologic and Molecular Characterization of 18 Sporadic Tumors Supports a Distinct Entity. Shah RB et al. American Journal of Surgical Pathology. 2019 Dec 31. PMID: 31850909. https://www.ncbi.nlm.nih.gov/pubmed/31850909 - The authors of this study provide insight into the characterization of renal neoplasms that are morphologically enriched for the presence of leiomyomatous stroma, including underlying molecular alterations.                                                                                                                                                              

Bladder Cancer

  • BCG is extensively used for the management of non-muscle invasive bladder cancer. However, significant shortages are anticipated in the coming year. This has been highlighted by the Bladder Cancer Advocacy Network (BCAN):                 https://bcan.org/bcg-shortage-bladder-cancer/#1560949642874-aab3abc1-db8e                                                                                                                      

Prostate Cancer

  • When and How Should Active Surveillance for Prostate Cancer be De-Escalated? Rajwa P et al. European Urology Focus. 2020. https://doi.org/10.1016/j.euf.2020.01.001 - Herein, the authors review available evidence and guidelines addressing transitions from active to passive monitoring for patients with low-risk prostate cancer.                                                                                                                                                                                                                                                              
  • Reporting Practices and Resource Utilization in the Era of Intraductal Carcinoma of the Prostate: A Survey of Genitourinary Subspecialists. Gandhi JS et al. American Journal of Surgical Pathology. 2019 Dec 23. PMID:  31876580.   https://www.ncbi.nlm.nih.gov/pubmed/31876580 - This report summarizes best practice recommendations related to diagnosis and reporting practices pertaining to intraductal carcinoma of the prostate.                                                                                                                                                                                                                                              
  • Management of Patients with Advanced Prostate Cancer: Report of the Advanced Prostate Cancer Consensus Conference 2019. Gillessen S et al. European Urology. 2020 Jan 27. PMID: 32001144. https://www.ncbi.nlm.nih.gov/pubmed/32001144 - This study summarizes expert opinion related to common issues and controversies regarding the management of patients with advanced prostate cancer, including metastatic hormone-sensitive and metastatic castration-resistant prostate cancer.

About GUPS

The Genitourinary Pathology Society (GUPS) was formed with the vision of advancing the care of patients with urologic diseases through enhancements of best practices, research, and education in the subspecialty of Urological Pathology.

GUPS is an official Companion Society of the United States and Canadian Academy of Pathology (USCAP).



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