Literature Watch & News: Genitourinary Pathology (April 2020- Lockdown edition) Sounak Gupta, MBBS, PhD and Rohit Mehra, MD.
Renal Cancer
• MiT family translocation renal cell carcinoma. Argani P. Semin Diagn Pathol. 2015 Mar;32(2):103-13. Review. PMID: 25758327. https://www.ncbi.nlm.nih.gov/pubmed/25758327 This review, authored by Dr. Pedram Argani, highlights the morphologic, translational and biologic features of MiT family aberration renal cell carcinoma. • Contemporary Renal Tumor Categorization With Biomarker and Translational Updates: A Practical Review. Taylor et al. Arch Pathol Lab Med. 2019 Dec;143(12):1477-1491. Review. PMID: 31765248. https://www.ncbi.nlm.nih.gov/pubmed/31765248 The authors of this study provide insight into the evolutionary biomarker landscape of renal cell carcinoma, incorporating established markers with upcoming markers of clinical potential.
Bladder Cancer
• Updates on the Genomics of Bladder Cancer and Novel Molecular Taxonomy. Al-Ahmadie H, Netto GJ. Adv Anat Pathol. 2020 Jan;27(1):36-43. Review. PMID: 31743118. https://www.ncbi.nlm.nih.gov/pubmed/31743118 This review provides an update on the recent advances in the molecular characterization and novel molecular taxonomy of urothelial carcinoma and its histologic variants. Prostate Cancer • Knowing what's growing: Why ductal and intraductal prostate cancer matter. Lawrence et al. Sci Transl Med. 2020 Mar 4;12(533). Review. PMID: 32132214. https://www.ncbi.nlm.nih.gov/pubmed/32132214 This review summarizes the pathologic, clinical and translational implications of ductal prostate cancer and intraductal prostate cancer. • Towards precision oncology in advanced prostate cancer. Ku et al. Nat Rev Urol. 2019 Nov;16(11):645-654. Review. PMID: 31591549. https://www.ncbi.nlm.nih.gov/pubmed/31591549 This review summarizes expert opinion related to concepts, common management issues and clinical applications for patients with advanced prostate cancer.
Testis Cancer
• Recently Described and Clinically Important Entities in Testis Tumors: A Selective Review of Changes Incorporated Into the 2016 Classification of the World Health Organization. Ulbright TM. Arch Pathol Lab Med. 2019 Jun;143(6):711-721. Review. PMID: 29949388. https://www.ncbi.nlm.nih.gov/pubmed/29949388
This review summarizes some common testicular pathologies with their clinical implications especially in light of the WHO classification of genitourinary tumors.
Penile Cancer
• Pathology of Invasive and Intraepithelial Penile Neoplasia. Canete-Portillo et al. Eur Urol Focus. 2019 Sep;5(5):713-717. Review. PMID: 31288989. https://www.ncbi.nlm.nih.gov/pubmed/31288989 This review summarizes an updated approach towards classification of penile intraepithelial neoplasia and penile invasive carcinoma. Miscellaneous • Next generation immunohistochemistry: Emerging substitutes to genetic testing? Andrici et al. Semin Diagn Pathol. 2018 May;35(3):161-169. Review. https://www.ncbi.nlm.nih.gov/pubmed/28662997 PMID: 28662997 This review elaborates on the utility of immunohistochemistry in detection of syndromic neoplasia (including genitourinary) from a surgical pathology perspective. Complimentary Courses •USCAP: Urologic Pathology, Course Director: Adeboye O. Osunkoya, MD Code: USCAPnvzcxw “Complimentary Access to eLearning from USCAP In response to the impact of the COVID-19 pandemic on pathology education, USCAP is currently providing complimentary access to eLearning modules (https://www.pathlms.com/uscap/courses/14759). This includes a section on Urologic Pathology, a course that is directed by Dr. Adeboye O. Osunkoya, MD, and includes sections on high yield prostate and bladder pathology (code: USCAPnvzcxw).”
About GUPS
The Genitourinary Pathology Society (GUPS) was formed with the vision of advancing the care of patients with urologic diseases through enhancements of best practices, research, and education in the subspecialty of Urological Pathology.
GUPS is an official Companion Society of the United States and Canadian Academy of Pathology (USCAP).
