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Literature Watch & News: Genitourinary Pathology (July 2020)

Sounak Gupta, MBBS, PhD and Rohit Mehra, MD.

Renal Cancer

ALK Rearranged Renal Cell Carcinoma (ALK-RCC): A Multi-Institutional Study of Twelve Cases With Identification of Novel Partner Genes CLIP1, KIF5B and KIAA1217.
Kuroda et al. Mod Pathol. 2020 May 28. PMID: 32467651

This study describes the clinicopathologic features of a series of 12 ALK rearranged renal cell carcinomas, including diverse morphologic features, and advocates for ALK immunohistochemistry-based screening of "unclassifiable RCCs".

• Next-generation RNA Sequencing-based Biomarker Characterization of Chromophobe Renal Cell Carcinoma and Related Oncocytic Neoplasms.

Skala et al. Eur Urol. 2020 Jul;78(1):63-74. PMID: 32299640

Herein, the authors evaluated RNA sequencing data from The Cancer Genome Atlas project to identify chromophobe renal cell carcinoma-specific biomarkers such as FOXI1, which are found to be localized to the intercalated cells of the distal nephron in non-neoplastic kidney tissue.

Bladder Cancer

European Association of Urology Guidelines on Upper Urinary Tract Urothelial Carcinoma: 2020 Update.
Roupret et al. Eur Urol. 2020 Jun 24;S0302-2838(20)30427-9. PMID: 32593530 https://pubmed.ncbi.nlm.nih.gov/32593530/
This manuscript summarizes the recommendations of the European Association of Urology (EAU) Guidelines Panel on current evidence-based management of Upper Urinary Tract Urothelial Carcinoma (UTUC) for routine clinical practice.
Variant Morphology and Random Chromosomal Integration of BK Polyomavirus in Posttransplant Urothelial Carcinomas.
Bertz et al. Mod Pathol. 2020 Jul;33(7):1433-1442. PMID: 32047230 https://pubmed.ncbi.nlm.nih.gov/32047230/

Herein, the authors have studied the pathogenic role of BK polyoma virus in the development of urothelial carcinoma following immune suppression in solid organ transplant recipients.

Prostate Cancer

The 2019 Genitourinary Pathology Society (GUPS) White Paper on Contemporary Grading of Prostate Cancer.
Epstein et al. Arch Pathol Lab Med . 2020 Jun 26. PMID: 32589068 https://pubmed.ncbi.nlm.nih.gov/32589068/
This manuscript summarizes the Genitourinary Pathology Society (GUPS) recommendations pertaining to contemporary grading of prostate cancer based on a critical review of the literature along with pathology and clinician surveys.
The 2019 International Society of Urological Pathology (ISUP) Consensus Conference on Grading of Prostatic Carcinoma.
Van Leenders et al. Am J Surg Pathol. 2020 May 26. PMID: 32459716 https://pubmed.ncbi.nlm.nih.gov/32459716/
This manuscript summarizes the International Society of Urological Pathology (ISUP) recommendations pertaining to contemporary grading of prostate cancer.
Role of Changes in Magnetic Resonance Imaging or Clinical Stage in Evaluation of Disease Progression for Men with Prostate Cancer on Active Surveillance.
Chestnut et al. Eur Urol. 2020 Apr;77(4):501-507. PMID:  31874726

Herein, the authors compare active surveillance protocols based on MRI or clinical stage changes compared with scheduled systematic biopsies to detect reclassification to grade group ≥2 disease.

    Testis Cancer

    Appendageal Tumors and Tumor-Like Lesions of the Testis and Paratestis: A 32-Years of Experience at a Single Institution.
    Al-Obaidy et al. Human Pathology, 2020 June 30; Electronic publication, ahead of print). PMID:  32619438
    This report summarizes a single institution experience of over 30 years pertaining to paratesticular tumors and tumors of testicular appendages.

    • Bilateral Synchronous Testicular Germ Cell Tumors in Children: Case Report and Review of the Literature.

    Kebudi et al. Urology. 2020 Jun;140:155-158. PMID: 32199873 https://pubmed.ncbi.nlm.nih.gov/32199873/
    This report highlights a case and summarizes relevant literature pertaining to bilateral testicular tumors in pediatric patients.

      Penile Cancer

      The Molecular Pathogenesis of Penile Carcinoma-Current Developments and Understanding.
      Emmanuel et al. Virchows Arch. 2019 Oct;475(4):397-405. PMID: 31243533 https://pubmed.ncbi.nlm.nih.gov/31243533/

      This review summarizes the literature pertaining to molecular drivers that govern penile carcinogenesis and their underlying prognostic and therapeutic importance.

      A Modified Histopathologic Staging in Penile Squamous Cell Carcinoma Predicts Nodal Metastasis and Outcome Better Than the Current AJCC Staging
      Sali et al. Am J Surg Pathol. 2020 Apr 14. PMID: 32301753

      Herein, the authors have reviewed 142 cases of penile squamous cell carcinoma.  This study evaluates the current AJCC staging system and suggests proposed modifications.


      •Prioritizing Urological Surgery in the COVID-19 Era: A Global Reflection on Guidelines.

      Gravas et al. Eur Urol Focus. 2020 Jun 15;S2405-4569(20)30164-4. PMID:  32571743

      This report evaluates the prioritization and management of urological procedures during the COVID-19 pandemic.
      The Multifaceted Long-Term Effects of the COVID-19 Pandemic on Urology.
      Morlacco et al. Nat Rev Urol. 2020 Jul;17(7):365-367. PMID:  32377015 https://pubmed.ncbi.nlm.nih.gov/32377015/
      This review aims to discuss COVID related effects for patients and Urology.

      About GUPS

      The Genitourinary Pathology Society (GUPS) was formed with the vision of advancing the care of patients with urologic diseases through enhancements of best practices, research, and education in the subspecialty of Urological Pathology.

      GUPS is an official Companion Society of the United States and Canadian Academy of Pathology (USCAP).



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