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Literature Watch & News: Genitourinary Pathology (October 2020)

Sounak Gupta, MBBS, PhD and Rohit Mehra, MD

Renal Cancer

Adverse histology, homozygous loss of CDKN2A/B, and complex genomic alterations in locally advanced/metastatic renal mucinous tubular and spindle cell carcinoma. 


Yang et al. Mod Pathol. 2020 Sep 2. [Online ahead of print]. PMID:  32879414

MET alterations in biphasic squamoid alveolar papillary renal cell carcinomas and clinicopathological features.


Denize et al. Mod Pathol. 2020 Aug 7. [Online ahead of print]. PMID:  32770124

Distinguishing Benign Renal Tumors with an Oncocytic Gene Expression (ONEX) Classifier.


McGillivray et al. Eur Urol. 2020 Sep 21;S0302-2838(20)30709-0.[Online ahead of print]. PMID:  32972793

Bladder Cancer

Primary Female Urethral Carcinoma: Proposed Staging Modifications Based on Assessment of Female Urethral Histology and Analysis of a Large Series of Female Urethral Carcinomas.


Aron et al. Am J Surg Pathol. 2020 Aug 28. [Online ahead of print]. PMID:  32868524


Clear Cell Adenocarcinoma in Men: A Series of 15 Cases.


Grosser et al. Am J Surg Pathol. 2020 Sep 21. [Online ahead of print]. PMID:  32960833 

Intestinal metaplasia of the urinary tract harbors potentially oncogenic genetic variants.


Acosta et al. Mod Pathol. 2020 Aug 28. [Online ahead of print]. PMID:  32860003

Prostate Cancer

Clinicopathologic Study of Gleason Pattern 5 Prostatic Adenocarcinoma With “Single-cell” Growth Reveals 2 Distinct Types, One With “Plasmacytoid” Features.


Nguyen et al. Am J Surg Pathol. 2020 Sep 25. [Online ahead of print]. PMID:  32991340

PIN‐like ductal carcinoma of the prostate has frequent activating RAS/RAF mutations.


Kaur et al. Histopathology. 2020 Aug 2.  [Online ahead of print].  PMID:  32740981

Head to head: should the intraductal component of invasive prostate cancer be graded?https://onlinelibrary.wiley.com/doi/10.1111/his.14216

Varma and Epstein. Histopathology. 2020 Jul 21.  [Online ahead of print]. PMID:  32692448 

Testis Cancer

Hepatoid Teratoma, Hepatoid Yolk Sac Tumor, and Hepatocellular Carcinoma: A Morphologic and Immunohistochemical Study of 30 Cases.


Al-Obaidy et al. Am J Surg Pathol. 2020 Sep 25. [Online ahead of print]. PMID:  32991342

The detection of isochromosome i[12p] in malignant germ cell tumours and tumours with somatic malignant transformation using qPCR.


Fichtner et al. Histopathology. 2020 Sep 24.  [Online ahead of print].  PMID:  32970854

Penile Cancer

Peyronie disease: a clinicopathologic study of 71 cases with emphasis on histopathologic patterns and prevalent metaplastic ossification.


Hatfield et al. Hum Pathol. 2020 Jul 15;104:9-17. PMID:  32681945


The Impact of the COVID-19 Pandemic on Genitourinary Cancer Care: Re-envisioning the Future.


Wallis et al. Eur Urol. 2020 Sep 3;S0302-2838(20)30676-X. [Online ahead of print]. PMID: 32893062

About GUPS

The Genitourinary Pathology Society (GUPS) was formed with the vision of advancing the care of patients with urologic diseases through enhancements of best practices, research, and education in the subspecialty of Urological Pathology.

GUPS is an official Companion Society of the United States and Canadian Academy of Pathology (USCAP).



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