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PREVIOUS Cases of the Week

2019-14 / May 13

84-year-old male with a history of follicular lymphoma, melanoma, and a 3.6 cm kidney mass, present with inguinal lymphadenopathy. Images are from biopsy of left inguinal lymph node.


2019-13 / May 6

54 yo male with a testicular mass. By immunohistochemistry, tumor cells are positive for cytokeratin AE1/AE3, desmin (perinuclear dot pattern) and WT1.


2019-12 / May 6

A 70 year old man underwent a 12 part needle biopsy of the prostate due to elevated serum PSA levels. In one part, an atypical focus at the end of the needle biopsy was noted.



2019-11 / April 29

A 57 year-old male underwent radical prostatectomy for Grade group 2 prostatic adenocarcinoma diagnosed on biopsy. Upon microscopic examination, a glandular lesion was identified in the left anterior prostate, in addition to a large tumor nodule of Grade group 2 cancer in the right posterior.  The following images are representative of the left anterior lesion which showed strong and diffuse staining with PAX2 (shown) and racemase, and negativity for PSA and WT-1. 


2019-10 / April 22

 A 67-year-old male with a 2.9 cm organ-confined renal mass.



2019-9 / April 15

A 65 year old man presented with a 3 mm nodule in the bladder.


2019-8 / April 8

A 35-year-old male presented with a 2-week history of discomfort and enlargement of the right testis. He was eventually treated with a right orchiectomy which revealed involvement by seminoma. Subsequently, he presented with early retroperitoneal relapse while on surveillance.



2019-7 / April 1

40-year-old female with a 4.5 cm solid and cystic renal mass. Images are from the radical nephrectomy specimen.


2019-6 / March 25

A 54 year old man presented with multiple bone metastases and a mass involving the bladder neck. A TUR of the bladder was performed. On outside stains, the tumor was negative for CD138, kappa and lambda light chains, CD56, CD45, CK7, HMWCK, AE1/3, desmin, and GATA3. Stains performed at our institution were positive for NKX3.1, P501S, PSA and negative for GATA3 and Uroplakin II. E-cadherin was lost in the tumor.

2019-5 / March 18

The cut surface of the kidney reveals a diffusely cystic appearance in an adult (Case 1) and in a separate pediatric patient (Case 2), respectively.


2019-4 / March 11
A 43-year-old male presented with a painless testicular mass. Representative histopathologic images and results of molecular testing are shown.


2019-3 / March 4
A 25 year old man was found to have a 5.0 cm. paratesticular mass.

2019-2 / February 25
A 79 year old male underwent a TURP due to obstruction. The tumor was stained at the outside institution and was diffusely positive for high molecular weight cytokeratin and negative for PSA, PSAP, GATA3, synaptophysin, with a ki67 of 90%.

2019-1 / February 18
68 year old male with large bladder mass. Transurethral resection is performed.


About GUPS

The Genitourinary Pathology Society (GUPS) was formed with the vision of advancing the care of patients with urologic diseases through enhancements of best practices, research, and education in the subspecialty of Urological Pathology.

GUPS is an official Companion Society of the United States and Canadian Academy of Pathology (USCAP).

Contact

gupathologysociety@gmail.com


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